D. Mrazek

Publications202
h-index47
Citations7,242
Highly Influential Citations284
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How common is attention-deficit/hyperactivity disorder? Incidence in a population-based birth cohort in Rochester, Minn.
TLDR
These results provide insight into the apparent discrepancies in estimates of the occurrence of AD/HD, with less stringent criteria resulting in higher cumulative incidence.
Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: a prospective cohort study.
TLDR
Cognitively normal elderly individuals who develop depression are at increased risk of subsequent MCI and a synergistic interaction between depression and apolipoprotein E genotype is found.
SLC6A4 variation and citalopram response
TLDR
It is suggested that multiple variations in the SLC6A4 gene are associated with remission in white non‐Hispanic depressed adults treated with citalopram, and the mechanism of action of these variants remains to be determined.
Problem behavior in early and middle childhood: an initial behavior genetic analysis.
TLDR
Results suggested that shared environmental influences may be more important in early childhood than in middle childhood, while the reverse holds for genetic influences.
A feeding scale for research and clinical practice to assess mother—infant interactions in the first three years of life
The Feeding Scale provides a reliable rating of mother-infant/toddler interactions during a 20-minute feeding in a laboratory setting. The scale consists of 46 mother and infant behaviors, which are…
Onset and persistence of childhood asthma: predictors from infancy.
TLDR
3 proved to have significant univariate relationships with asthma between ages 6 and 8: elevated IgE levels measured when the children were 6 months of age, global ratings of parenting difficulties measured when infants were 3 weeks old, and higher numbers of respiratory infections in the first year of life.
Evolution and revolution in child psychiatry: ADHD as a disorder of adaptation.
TLDR
The authors examine attention-deficit/hyperactivity disorder (ADHD) in relation to evolutionary theories of psychology and biology and clarify the potentially adaptive nature of characteristics of inattention, impulsivity, and motoric hyperactivity, depending on the nature of child's environments.
A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013.
TLDR
Treatment-resistant depression may present an annual added societal cost of $29-$48 billion, pushing up the total societal costs of major depression by as much as $106-$118 billion, and underscore the need for research on the mechanisms of depression, new therapeutic targets, existing and new treatment combinations, and tests to improve the efficacy of and adherence to treatments for treatment- resistant depression.
CYP2C19 variation and citalopram response
TLDR
Variations in CYP2C19 were associated with tolerance and remission in a large sample of White non-Hispanic patients treated with citalopram, despite several limitations including the lack of serum drug levels.
Psychiatric pharmacogenomic testing in clinical practice
  • D. Mrazek
  • Biology, Medicine
    Dialogues in clinical neuroscience
  • 1 March 2010
TLDR
Genotyping the highly variable cytochrome P 4 5 0 2D 6 gene now provides clinicians with the opportunity to identify both poor metabolizers and ultrarapid metabolizers of 2D6 substrate medications.
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