• Publications
  • Influence
Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans
In response to environmental and dietary cues, the C. elegans orphan nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat metabolism, and life span. Despite strongExpand
  • 393
  • 27
  • PDF
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
Broad aspects of Caenorhabditis elegans life history, including larval developmental timing, arrest at the dauer diapause, and longevity, are regulated by the nuclear receptor DAF-12. EndogenousExpand
  • 206
  • 18
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which serves as a ligand to the nuclear hormone receptor DAF-12. A key step in hormone production isExpand
  • 162
  • 18
  • PDF
De-orphanization of Cytochrome P450 2R1
The conversion of vitamin D into an active ligand for the vitamin D receptor requires 25-hydroxylation in the liver and 1α-hydroxylation in the kidney. Mitochondrial and microsomal vitamin DExpand
  • 310
  • 13
  • PDF
A TALEN genome-editing system for generating human stem cell-based disease models.
Transcription activator-like effector nucleases (TALENs) are a new class of engineered nucleases that are easier to design to cleave at desired sites in a genome than previous types of nucleases. WeExpand
  • 479
  • 11
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes
Nematode parasitism is a worldwide health problem resulting in malnutrition and morbidity in over 1 billion people. The molecular mechanisms governing infection are poorly understood. Here, we reportExpand
  • 93
  • 8
  • PDF
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
Background & Aims Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholicExpand
  • 105
  • 6
Oligomerization and Regulated Proteolytic Processing of Angiopoietin-like Protein 4*
Angiopoietin-like protein 4 (Angptl4) is a recently identified circulating protein expressed primarily in adipose tissue and liver. Also known as peroxisome proliferator-activated receptor (PPAR)-γExpand
  • 127
  • 3
The Rieske oxygenase DAF‐36 functions as a cholesterol 7‐desaturase in steroidogenic pathways governing longevity
Bile acids are cholesterol‐derived signaling molecules that regulate mammalian metabolism through sterol‐sensing nuclear receptor transcription factors. In C. elegans, bile acid‐like steroids calledExpand
  • 50
  • 3
Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins
BackgroundHepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are the primary cell typeExpand
  • 44
  • 2
  • PDF