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Posttranslational regulation impacts the fate of duplicated genes
Gene and genome duplications create novel genetic material on which evolution can work and have therefore been recognized as a major source of innovation for many eukaryotic lineages. FollowingExpand
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The complex evolutionary history of aminoacyl-tRNA synthetases
Abstract Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes responsible for the faithful translation of the genetic code and have lately become a prominent target for syntheticExpand
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Discovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes
Considering that 70% of our planet’s surface is covered by oceans, it is likely that undiscovered biodiversity is still enormous. A large portion of marine biodiversity consists of microbiomes. TheyExpand
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Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics
Non-ribosomal peptide synthetases (NRPS) and type-I polyketide synthases (PKS-I) are multimodular enzymes involved in biosynthesis of oligopeptide and polyketide secondary metabolites produced byExpand
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Detection of a phylogenetically distinct IMP-type metallo-β-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio).
OBJECTIVES To characterize a highly divergent IMP-type metallo-β-lactamase (MBL) variant detected in a multidrug-resistant Pseudomonas aeruginosa clinical isolate. METHODS P. aeruginosa isolateExpand
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Cyanogenesis by the entomopathogenic bacterium Pseudomonas entomophila
Aims:  To investigate whether the entomopathogenic bacterium Pseudomonas entomophila can synthesize hydrogen cyanide (HCN).
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Siderophores in fluorescent pseudomonads: new tricks from an old dog.
Iron is an essential nutrient for almost all bacteria; however, at neutral pH its bioavailability is limited. Siderophores are iron-binding compounds of low molecular weight that enable theExpand
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Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases.
The majority of nonribosomal peptide synthases and type I polyketide synthases are multimodular megasynthases of oligopeptide and polyketide secondary metabolites, respectively. Owing to theirExpand
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Role of siderophores in cystic fibrosis pathogenesis: foes or friends?
Cystic fibrosis (CF) is one of the most common genetic disorders among Caucasians. CF patients are susceptible to chronic lung infections caused by diverse microorganisms, therefore CF should beExpand
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Intra- and inter-serotypic recombinations in the 5΄ UTR-VP4 region of Echovirus 30 strains
Recombination has been recognized as a major mechanism of evolution in enteroviruses. The Echovirus 30 (E-30) strain Gior was sequenced and phylogenetically compared to all available E-30 sequencesExpand
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