D. Morrison

Publications161
h-index42
Citations9,257
Highly Influential Citations646
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Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
The 2,160,837–base pair genome sequence of an isolate of Streptococcus pneumoniae, a Gram-positive pathogen that causes pneumonia, bacteremia, meningitis, and otitis media, contains 2236 predicted… Expand
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An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae.
Competence for genetic transformation in Streptococcus pneumoniae has been known for three decades to arise in growing cultures at a critical cell density, in response to a secreted… Expand
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Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays
Natural genetic transformation in Streptococcus pneumoniae is controlled in part by a quorum‐sensing system mediated by a peptide pheromone called competence‐stimulating peptide (CSP), which acts to… Expand
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An rpsL Cassette, Janus, for Gene Replacement through Negative Selection in Streptococcus pneumoniae
ABSTRACT Natural genetic transformation offers a direct route by which synthetic gene constructs can be placed into the single circular chromosome of Streptococcus pneumoniae. However, the lack of a… Expand
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A novel double‐tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator
All streptococcal genomes encode the alternative sigma factor SigX and 21 SigX‐dependent proteins required for genetic transformation, yet no pyogenic streptococci are known to develop competence.… Expand
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Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation.
Competence for genetic transformation in Streptococcus pneumoniae is regulated by a quorum-sensing system encoded by two genetic loci, comCDE and comAB. Additional competence-specific operons, cilA,… Expand
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Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto‐induced peptide pheromone and a two‐component regulatory system
The regulation of competence for genetic transformation in Streptococcus pneumoniae depends on a quorum‐sensing system, but the only molecular elements of the system whose specific role have been… Expand
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Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone.
The nucleotide sequence of comC, the gene encoding the 17-residue competence-stimulating peptide (CSP) of Streptococcus pneumoniae (L. S. Havarstein, G. Coomaraswamy, and D. A. Morrison, Proc. Natl.… Expand
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Development of competence for genetic transformation of Streptococcus mutans in a chemically defined medium.
Streptococcus mutans develops competence for genetic transformation in response to regulatory circuits that sense at least two peptide pheromones. One peptide, known as CSP, is sensed by a… Expand
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PCR ligation mutagenesis in transformable streptococci: application and efficiency.
PCR ligation mutagenesis is a novel technique that can easily be adapted for many gene modification purposes. Successful application of this versatile technique involves sequence identification of… Expand
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