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Modeling Klebsiella pneumoniae Pathogenesis by Infection of the Wax Moth Galleria mellonella
TLDR
The Galleria model of G. mellonella models some of the known features of Klebsiella-induced pneumonia, i.e., cell death associated with bacterial replication, avoidance of phagocytosis by phagocytes, and the attenuation of host defense responses, chiefly the production of antimicrobial factors. Expand
Analysis of the Networks Controlling the Antimicrobial-Peptide-Dependent Induction of Klebsiella pneumoniae Virulence Factors
TLDR
The findings support the notion that Klebsiella activates a defense program against APs that is controlled by three signaling systems, and therapeutic strategies directed to prevent the activation of this program could be a new approach worth exploring to facilitate the clearance of the pathogen from the airways. Expand
Dissection of Host Cell Signal Transduction during Acinetobacter baumannii – Triggered Inflammatory Response
TLDR
It is demonstrated that airway epithelial cells produce mediators important for A. baumannii clearance, including lipopolysaccharide, which matches those with endotoxic potential. Expand
Role of Bacterial Surface Structures on the Interaction of Klebsiella pneumoniae with Phagocytes
TLDR
A correlation between virulence, using the pneumonia mouse model, and resistance to phagocytosis is found and supports the notion that Dictyostelium amoebae might be useful as host model to measure K. pneumoniae virulence and not only phagcytosis. Expand
Klebsiella pneumoniae Capsule Polysaccharide Impedes the Expression of β-Defensins by Airway Epithelial Cells
TLDR
K. pneumoniae CPS not only protects the pathogen from the bactericidal action of defensins but also impedes their expression, which may facilitate pathogen survival in the hostile environment of the lung. Expand
The trivial function of sleep.
TLDR
It is argued that the function of sleep could be trivial for mammals and birds because sleep does not provide additional advantages over simple rest, and it is proposed that few, if any, phenotypic selectable traits do exist in sleep. Expand
Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes
TLDR
Evidence is proved that K. pneumoniae survives killing by macrophages by manipulating phagosome maturation that may contribute to Klebsiella pathogenesis, and the capsule is dispensable for KlebsIElla intracellular survival if bacteria were not opsonized. Expand
Deciphering tissue-induced Klebsiella pneumoniae lipid A structure
TLDR
It is demonstrated that Klebsiella remodels its lipid A in a tissue-dependent manner, and deciphering the lipid A expressed in vivo opens the possibility of designing novel therapeutics targeting the enzymes responsible for the in vivo lipid A pattern. Expand
Molecular Basis of Yersinia enterocolitica Temperature-Dependent Resistance to Antimicrobial Peptides
TLDR
Findings support the notion that the temperature-dependent regulation of loci controlling lipid A modifications could be explained by H-NS-dependent negative regulation alleviated by RovA, and demonstrate that PhoPQ and PmrAB regulate positively the expression of rovA, the effect of PhOPQ being more important. Expand
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
TLDR
The positive effects of polyphenols on the prevention of the changes that occur during aging in the brain and their consequences on cognition are described, emphasizing the possible modulation of inflammaging bypolyphenols through a SIRT1-mediated mechanism. Expand
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