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Protein-protein interactions in the membrane: sequence, structural, and biological motifs.
Single-span transmembrane (TM) helices have structural and functional roles well beyond serving as mere anchors to tether water-soluble domains in the vicinity of the membrane. They frequently directExpand
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Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment
Binding of the talin-1 FERM (4.1/ezrin/radixin/moesin) domain to the β3 cytosolic tail causes activation of the integrin αIIbβ3. The FERM domain also binds to acidic phospholipids. Although much isExpand
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NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation
The integrin αIIbβ3 is a transmembrane (TM) heterodimeric adhesion receptor that exists in equilibrium between resting and active ligand binding conformations. In resting αIIbβ3, the TM andExpand
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Digestible Lysine Requirements of Male Turkeys During the 12 to 18 Week Period
Two floor pen trials were conducted using turkey toms in order to determine the digestible lysine requirement for the 72 to 83 and 84 to 95 day feeding periods. Prior to the studies, birds were fed aExpand
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Activation of Platelet αIIbβ3 by an Exogenous Peptide Corresponding to the Transmembrane Domain of αIIb*>
A transmembrane domain heterodimer, acting in concert with a membrane-proximal cytoplasmic domain clasp, is thought to maintain integrins in a low affinity state. To test whether helix-helixExpand
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Scoliosis-Specific Information on the Internet: Has the “Information Highway” Led to Better Information Provision?
Study Design. A quality-control Internet-based study using recognized quality scoring systems. Objective. To evaluate the quality of information available on the Internet. Summary of Background Data.Expand
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Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.
Signal transduction across biological membranes is central to life. This process generally happens through communication between different domains and hierarchical coupling of information. Here, weExpand
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A Focused Addiction Curriculum and Its Impact on Student Knowledge, Attitudes, and Confidence in the Treatment of Patients with Substance Use
BackgroundAssessment of attitudes towards addiction in medical students has largely gone unexplored. This study examines the impact of a supplemental substance use disorder curriculum in theExpand
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The clinical characteristics and impact of laryngopharyngeal reflux disease on health-related quality of life.
BACKGROUND AND OBJECTIVES Although it is accepted that reflux of stomach acid causes gastroesophageal reflux disease (GERD), it is less well understood that it also contributes to the clinical signsExpand
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