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Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
TLDR
It is proposed that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity. Expand
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
TLDR
Evidence is provided for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system, because of its crucial role in the host physiology and health status. Expand
Increased cytokine production in mononuclear cells of healthy elderly people
TLDR
The increased production of pro‐inflammatory cytokines by stimulated mononuclear cells of healthy aged subjects may be relevant to several aspects of age‐associated pathological events, including atherosclerosis, osteoporosis, fibrosis and dementia. Expand
Gut Microbiota and Extreme Longevity
TLDR
This work provides for the first time the phylogenetic microbiota analysis of semi-supercentenarians, i.e., 105-109 years old, in comparison to adults, elderly, and centenarian, thus reconstructing the longest available human microbiota trajectory along aging. Expand
Sleep in schizophrenia patients and the effects of antipsychotic drugs.
TLDR
The sleep disturbances of either never-medicated or previously treated schizophrenia patients are characterized by a sleep-onset and maintenance insomnia, and the atypical antipsychotics olanzapine, risperidone, and clozapine significantly increase total sleep time and stage 2 sleep. Expand
Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians.
TLDR
The data suggest that in centenarians some immune responses are kept at a high level of efficiency, likely contributing to their successful aging, as shown by the progressive derangement of a variety of immune parameters. Expand
A gender–dependent genetic predisposition to produce high levels of IL‐6 is detrimental for longevity
TLDR
The data suggest that those individuals who are genetically predisposed to produce high levels of IL‐6 during aging, i.e. –174 locus GG homozygous men, are disadvantaged for longevity. Expand
The immune system in extreme longevity
TLDR
The frequency and the absolute number of viral antigen-specific CD8+ T-cells in subjects older than 85 years, who were serologically positive for CMV or EBV are determined and underlines the importance of chronic antigenic stimulation in the pathogenesis of the main immunological alterations of aging. Expand
Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm‐aging”
TLDR
It is shown that circulating mtDNA increases with age, and can significantly contribute to the maintenance of the low‐grade, chronic inflammation observed in elderly people. Expand
Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood
TLDR
The data suggest that the immunological consequences of stress do not simply overlap with psychological and endocrine alterations, and are particularly severe and long-lasting in a subgroup of subjects, indicating the importance of individual variability in the capacity to cope with stress. Expand
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