• Publications
  • Influence
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain
The distribution of NMDA-sensitive L-[3H]glutamate-binding sites suggests that the NMDA receptor represents a major, distinct subset of excitatory amino acid receptors and indicates regions in which neurotransmission may be mediated or modulated by this receptor. Expand
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.
'The following abbreviations have been used in the text; I3-L-ODAP, I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a­Expand
Structure–activity analysis of a novel NR2C/NR2D‐preferring NMDA receptor antagonist: 1‐(phenanthrene‐2‐carbonyl) piperazine‐2,3‐dicarboxylic acid
PPDA is the most potent and selective NR2C/NR2D‐preferring antagonist yet reported and thus may be useful in defining NR2 C/ NR2D function and developing related antagonists with improved NMDA receptor subtype selectivity. Expand
Anatomical organization of excitatory amino acid receptors and their pathways
Evidence obtained with presynaptic markers indicates that EAA are major transmitters of corticocortical, corticofugal, and sensory systems and this anatomical map appears to correspond to the distribution of the sum of the receptors. Expand
The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition
The anatomical distribution of the four NMDA receptor subtypes strikingly parallels the distribution of mRNA encoding NR2A-D subunits, suggesting that the four previously identified native NMDAceptor subtypes differ in their NR2 composition. Expand
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus
Long‐term potentiation (LTP) induced by successive rounds of burst stimulation is accompanied by a long‐term increase in the contribution of extrasynaptic receptors in the afterburst EPSCNMDA. Expand
Calcium‐permeable AMPA receptors containing Q/R‐unedited GluR2 direct human neural progenitor cell differentiation to neurons
Calcium‐permeable AMPA receptors containing Q/R‐unedited GluR2 direct human neural progenitor cell differentiation to neurons and provides a possible explanation for why the Q/ R editing process exists. Expand
NR2B‐ and NR2D‐containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones
It is proposed that NR1/NR 2B/NR2D triheteromers form a significant fraction of synaptic NMDA receptors during postnatal development, the first report of data suggesting NR2D‐containing triheteromericNMDA receptors at a brain synapse. Expand
The NMDA receptor as a target for cognitive enhancement
There is good evidence that both positive and negative modulation can enhance function suggesting that a subtle approach correcting imbalances in particular clinical situations will be required and excessive activation and the resultant deleterious effects will need to be carefully avoided. Expand
The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography
The distribution of [3H]kainic acid binding sites in the rat CNS was determined by in vitro autoradiography and suggest that KA binding sites are associated with select terminal fields, and hence may be involved in neurotransmission in certain CNS pathways. Expand