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Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical impact in improving overall survival of several malignancies associated with poor outcomes; however, only 20–40% of patientsExpand
Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report
Abstract: Ten years ago, a consensus report on the optimization of tacrolimus was published in this journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International AssociationExpand
Sirolimus and everolimus in kidney transplantation.
The mammalian target of rapamycin (mTOR) inhibitors sirolimus and everolimus have shown their efficacy in kidney transplantation, but their wider introduction has been limited by relative highExpand
Population Pharmacokinetics and Pharmacogenetics of Everolimus in Renal Transplant Patients
Background and ObjectiveEverolimus is a novel macrolide immunosuppressant used in the prevention of acute and chronic rejection of solid organ transplants. Everolimus is being actively investigatedExpand
Early Conversion to Prednisolone/Everolimus as an Alternative Weaning Regimen Associates With Beneficial Renal Transplant Histology and Function: The Randomized‐Controlled MECANO Trial
In renal transplantation, use of calcineurin inhibitors (CNIs) is associated with nephrotoxicity and immunosuppression with malignancies and infections. This trial aimed to minimize CNI exposure andExpand
Interstitial pneumonitis caused by everolimus: a case–cohort study in renal transplant recipients
The use of inhibitors of the mammalian target of rapamycin (mTORi) in renal transplantation is associated with many side effects, the potentially most severe being interstitial pneumonitis. SeveralExpand
Tamoxifen Pharmacogenetics and Metabolism: Results From the Prospective CYPTAM Study.
PURPOSE Tamoxifen is widely prescribed as adjuvant therapy in patients with early-stage breast cancer. It has been postulated that concentrations of endoxifen, the active metabolite of tamoxifen, areExpand
Severe COVID‐19 in a renal transplant recipient: A focus on pharmacokinetics
The current coronavirus disease 2019 (COVID‐19) pandemic requires extra attention for immunocompromised patients, including solid organ transplant recipients. We report on a case of a 35‐year‐oldExpand
High interpatient variability of treosulfan exposure is associated with early toxicity in paediatric HSCT: a prospective multicentre study
Treosulfan‐based conditioning is increasingly employed in paediatric haematopoietic stem cell transplantation (HSCT). Data on treosulfan pharmacokinetics in children are scarce, and the relationshipExpand
A Review of Mathematical Models for Tumor Dynamics and Treatment Resistance Evolution of Solid Tumors
We comprehensively summarized mathematical models of tumor dynamics for solid tumors and of drug resistance evolution during treatment for patients with solid tumors. Expand