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Stimulation of B-cell progenitors by cloned murine interleukin-7
TLDR
A bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors and a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7 is isolated.
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B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors
TLDR
A biological assay system is used to biochemically purify a previously uncharacterized murine lymphopoietic growth factor designated lymphopOietin 1 (LP-1), capable of stimulating the proliferation and extended maintenance of precursor cells of the B lineage.
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Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.
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Interleukin 2: A Class of T Cell Growth Factors
ABBREVIATIONS: IL 1 IL 2 Con A CTL HT FCS DEAE lEF LAF LPS MTLC pi PHA SRBC TCGF TSF TRF Interleukin 1 Interleukin 2 Concanavalin A cytotoxic T lymphocytes helper T lymphocytes fetal calf serum…
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Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor.
TLDR
This purified human recombinant GM-CSF stimulated peripheral blood monocytes in vitro to become cytotoxic for the malignant melanoma cell line A375 and stimulated T cell-derived lymphokine, gamma-interferon, to become tumoricidal against this malignant cell line.
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Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines
TLDR
The data have been interpreted as showing the two molecular forms of murine TCGF (pI 4.3 and 4.9) are responsible for many of the lymphokine activities described elsewhere as thymocyte mitogenic factor, nonspecific T-cell-replacing factor and killer helper factor or costimulator.
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Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.
TLDR
Serologic analysis using a monoclonal antibody against purified recombinant interleukin 1 alpha proved conclusively that the potentiating activity in HBT 5637 serum-free supernatants is due to interlekina 1 alpha.
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Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines
TLDR
It is concluded that BSF-1 is both a growth factor and a differentiation factor that stimulated the proliferation of several IL-2- and IL-3-dependent cell lines and suggested additional biologic properties of B SF-1 on lineages besides B lymphocytes.
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Biochemical and biologic characterization of lymphocyte regulatory molecules. VIII. Purification of interleukin 2 from a human T cell leukemia.
TLDR
Techniques used to isolate human IL 2 from Jurkat supernatants and the biochemical properties of the resulting material are described, which are capable of stimulating mouse as well ashuman IL 2-dependent cell lines.
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Molecular Characterization of Interleukin 2
TLDR
The biochemical properties of human and murine IL 2 are summarized and RNA encoding for IL 2 may be useful for the development of probes to isolate lymphokine genes.
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