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Stimulation of B-cell progenitors by cloned murine interleukin-7
A bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors and a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7 is isolated. Expand
B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors
A biological assay system is used to biochemically purify a previously uncharacterized murine lymphopoietic growth factor designated lymphopOietin 1 (LP-1), capable of stimulating the proliferation and extended maintenance of precursor cells of the B lineage. Expand
Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.
The rapid phosphorylation/dephosphorylation of T4 as well as its movement from the cell surface suggest that T4 functions as a receptor for an unknown ligand. Expand
Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines
The data have been interpreted as showing the two molecular forms of murine TCGF (pI 4.3 and 4.9) are responsible for many of the lymphokine activities described elsewhere as thymocyte mitogenic factor, nonspecific T-cell-replacing factor and killer helper factor or costimulator. Expand
Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.
Serologic analysis using a monoclonal antibody against purified recombinant interleukin 1 alpha proved conclusively that the potentiating activity in HBT 5637 serum-free supernatants is due to interlekina 1 alpha. Expand
Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines
It is concluded that BSF-1 is both a growth factor and a differentiation factor that stimulated the proliferation of several IL-2- and IL-3-dependent cell lines and suggested additional biologic properties of B SF-1 on lineages besides B lymphocytes. Expand
Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor.
This purified human recombinant GM-CSF stimulated peripheral blood monocytes in vitro to become cytotoxic for the malignant melanoma cell line A375 and stimulated T cell-derived lymphokine, gamma-interferon, to become tumoricidal against this malignant cell line. Expand
Biochemical and biologic characterization of lymphocyte regulatory molecules. VIII. Purification of interleukin 2 from a human T cell leukemia.
Techniques used to isolate human IL 2 from Jurkat supernatants and the biochemical properties of the resulting material are described, which are capable of stimulating mouse as well ashuman IL 2-dependent cell lines. Expand
Molecular Characterization of Interleukin 2
The biochemical properties of human and murine IL 2 are summarized and RNA encoding for IL 2 may be useful for the development of probes to isolate lymphokine genes. Expand
Biochemical comparison of murine colony-stimulating factors secreted by a T cell lymphoma and a myelomonocytic leukemia.
Factors that stimulate the proliferation and differentiation of murine bone marrow cells have been purified from a cloned T cell lymphoma, LBRM-33, and a cloned myelomonocytic leukemia cell line,Expand