• Publications
  • Influence
Hydration regulates thermodynamics of G-quadruplex formation under molecular crowding conditions.
The effect of molecular crowding on the structure and stability of biomolecules has become a subject of increasing interest because it can clarify how biomolecules behave under cell-mimickingExpand
  • 211
  • 6
Roles of Mg2+ in TPP‐dependent riboswitch
We quantified the effect of Mg2+ on thiamine pyrophosphate (TPP) binding to TPP‐dependent thiA riboswitch RNA. The association constant of TPP binding to the riboswitch at 20 °C increased from 1.2 ×Expand
  • 71
  • 5
Molecular crowding effects on structure and stability of DNA.
Living cells contain a variety of biomolecules including nucleic acids, proteins, polysaccharides, and metabolites as well as other soluble and insoluble components. These biomolecules occupy aExpand
  • 193
  • 4
Characterization of structure and stability of long telomeric DNA G-quadruplexes.
In the current study, we used a combination of gel electrophoresis, circular dichroism, and UV melting analysis to investigate the structure and stability of G-quadruplexes formed by long telomericExpand
  • 146
  • 3
Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes
Cyclin A(2) IS a prognostic indicator in early-stage cancer. However, since most of peptide-protein bindings do not produce an easily measurable output signal, this severely hinders homogeneousExpand
  • 116
  • 3
Molecular crowding regulates the structural switch of the DNA G-quadruplex.
Almost all biochemical reactions in vitro have been investigated through numerous experiments conducted in dilute solutions containing low concentrations of solutes. However, biomacromolecules suchExpand
  • 135
  • 2
Beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions.
The structure and stability of long telomeric DNAs, (T(2)AG(3))(n) (n = 4-20), were studied under dilute and molecular crowding conditions in the presence of Na(+) and K(+). Structural analysisExpand
  • 70
  • 2
Long RNA dangling end has large energetic contribution to duplex stability.
Long terminal unpaired nucleotides known as dangling ends play interesting roles in biological systems. Previous studies, however, only dealt with the energy contributions of single dangling bases.Expand
  • 57
  • 2
Effect of divalent cations on antiparallel G‐quartet structure of d(G4T4G4)
The thermodynamic parameters of an antiparallel G‐quartet formation of d(G4T4G4) with 1 mM divalent cation (Mg2+, Ca2+, Mn2+, Co2+, and Zn2+) were obtained. The thermodynamic parameters showed thatExpand
  • 65
  • 2