D. Mitchell

Publications210
h-index57
Citations10,646
Highly Influential Citations380
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CELL SURVIVAL CHARACTERISTICS AND MOLECULAR RESPONSES OF ANTARCTIC PHYTOPLANKTON TO ULTRAVIOLET‐B RADIATION 1
TLDR
Comparison of cellular responses associated with photoenhanced repair and nucleotide excision (“dark”) repair indicated that light‐mediated correction of UV damage was an important factor in cell survival, and a general dependence of photoproduct induction and D37 values on cell size and shape was indicated. Expand
Solar UVB-induced DNA damage and photoenzymatic DNA repair in antarctic zooplankton.
TLDR
It is suggested that increased solar UV may reduce recruitment and adversely affect trophic transfer of productivity by affecting heterotrophic species as well as primary producers. Expand
THE BIOLOGY OF THE (6–4) PHOTOPRODUCT
TLDR
The data reviewed in this article support the notion that the (6-4) photoproduct and its Dewar photoisomer are important cytotoxic determinants of UV light. Expand
Diel and depth profiles of DNA photodamage in bacterioplankton exposed to ambient solar ultraviolet radiation
TLDR
It is shown that bacteria are more susceptible to UV-B damage and may be as a more sensitive indicator of UV stress than other microorganisms, and wave action and mixing strongly influence the effects ofUV-B in surface waters, demonstl-ating that UV- B effects may not always be predictable from measures of UV radiatio~ attenuation. Expand
Inhibition of bacterial activities by solar radiation in nearshore waters and the Gulf of Mexico
The effects of ultraviolet ( U V ) r a d ~ a t ~ o n on thymldine and leucine incorporation were evarmned In surface waters from the Gulf of Mexico and Santa Rosa Sound a mesotrophlc estuary In no]… Expand
A UV-sensitive mutant of Arabidopsis defective in the repair of pyrimidine-pyrimidinone(6-4) dimers.
TLDR
In wild-type seedlings, repair of cyclobutane pyrimidine dimers occurred more slowly in the dark than in the light; repair of this photoproduct was not affected in the mutant. Expand
The Induction and Repair of DNA Photodamage in the Environment
Since its discovery in bacteria 25 years ago, DNA repair, particularly in response to damage induced by UV radiation, has been a major focus of molecular biology. The roles played by DNA damage and… Expand
Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation
TLDR
Findings suggest that E2F1 participates in the response to UVB by promoting DNA repair and suppressing apoptosis, and is independent of p53. Expand
THE RELATIVE CYTOTOXICITY OF(6–4) PHOTOPRODUCTS AND CYCLOBUTANE DIMERS IN MAMMALIAN CELLS *
  • D. Mitchell
  • Chemistry, Medicine
  • Photochemistry and photobiology
  • 1 July 1988
TLDR
Photochemical data indicate that the pyrimidine(6‐4)pyrimidone photoproduct is induced at a substantial frequency compared to the cyclobutane dimer and that the action spectra for the induction of both lesions are equivalent. Expand
Long-term persistence of bacterial DNA
TLDR
This is the first study of DNA durability and degradation of a broad variety of bacteria preserved under optimal frozen conditions, using rigorous ancient DNA methods and demonstrates that nonspore-forming gram-positive Actinobacteria are by far the most durable, out-surviving endosporeformers such as Bacillaceae and Clostridiaceae. Expand
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