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The effects of cycloheximide on the biosynthesis and secretion of proteoglycans by chondrocytes in culture.
Proteoglycans synthesized by rat chondrosarcoma cells in culture are secreted into the culture medium through a pericellular matrix. The appearance of [35S]sulphate in secreted proteoglycan after a 5… Expand
The control of chondroitin sulphate biosynthesis and its influence on the structure of cartilage proteoglycans.
Chondroitin sulphate synthesis on proteoglycans was decreased in rat chondrosarcoma cell cultures in the presence of cycloheximide (0.1-1.0 muM) or p-nitrophenyl beta-D-xyloside (50 microM). In the… Expand
Monensin inhibits synthesis of proteoglycan, but not of hyaluronate, in chondrocytes.
Monensin (10nm-1mum) inhibited the incorporation of [(35)S]sulphate and [(3)H]glucosamine into proteoglycans by rat chondrosarcoma cells, but the incorporation of [(3)H]glucosamine into hyaluronate… Expand
Characteristics of lipopolysaccharide interaction with human peripheral-blood monocytes.
The interaction between radioiodinated lipopolysaccharide from Escherichia coli 0111:B4 (125I-LPS) and human peripheral-blood monocytes was studied. The association of 125I-LPS with monocytes at 37… Expand
Dose-dependent reduction of lipopolysaccharide pyrogenicity by polymyxin B.
- S. Warner, D. Mitchell, N. Savage, E. Mcclain
- Biology, Medicine
- Biochemical pharmacology
- 15 November 1985
Lipopolysaccharides (LPS) from Gram-negative bacteria are potent pyrogens in mammals. Polymyxin B (PB), a cationic polypeptide antibiotic, binds lipid A, the active moiety of LPS, with high affinity… Expand