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EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.
It is shown that the human pathogen Staphylococcus aureus secretes EsxA and EsxB, ESAT-6-like proteins, across the bacterial envelope, suggesting that this specialized secretion system may be a general strategy of human bacterial pathogenesis. Expand
Modulation of the Escherichia coliσE (RpoE) heat‐shock transcription‐factor activity by the RseA, RseB and RseC proteins
The σE (RpoE) transcription factor of Escherichia coli regulates the expression of genes whose products are devoted to extracytoplasmic activities and is further modulated by the products of the remaining genes in this operon, rseB and rseC. Expand
Passage of Heme-Iron Across the Envelope of Staphylococcus aureus
Isd appears to act as an import apparatus that uses cell wall–anchored proteins to relay heme-iron across the bacterial envelope. Expand
New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH
It is proposed that these three proteins (SurA, FkpA and OmpH/Skp) play an active role either as folding catalysts or as chaperones in extracytoplasmic compartments. Expand
The extracytoplasmic function sigma factors: role and regulation
Alternative sigma factors provide a means of regulating gene expression in response to various extracellular changes. One such class of sigma factors appears to control a variety of functions,Expand
The rpoE gene encoding the sigma E (sigma 24) heat shock sigma factor of Escherichia coli.
In vivo and in vitro analyses of rpoE transcriptional regulation showed that the r poE gene is transcribed from two major promoters, one of which is positively regulated by sigma E itself. Expand
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues
Staphylococcus aureus infections are associated with abscess formation and bacterial persistence; however, the genes that enable this lifestyle are not known and insertional variants in genes for cell wall‐anchored surface proteins are tested to infer the stage at which these molecules function. Expand
EsaC substrate for the ESAT‐6 secretion pathway and its role in persistent infections of Staphylococcus aureus
The data suggest a model whereby EsaB controls the production of effector molecules that are important for host pathogen interaction, and one such effector, EsaC, is a secretion substrate of the Ess pathway and implements its pathogenic function during infection. Expand
Identification and characterization of a new disulfide isomerase‐like protein (DsbD) in Escherichia coli.
The finding that overexpression of DsbD leads to a Dsb‐ phenotype, very similar to that exhibited by dsbA null mutants, is in good agreement with such a model. Expand
Characterization of the Yersinia enterocolitica Type III Secretion ATPase YscN and Its Regulator, YscL
By studying the biochemical properties of YscN and YscL of Yersinia enterocolitica, this work has characterized them as the ATPase and ATPase regulator, respectively, of the type III secretion system of this organism. Expand