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Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism.
TLDR
Evidence for the presence of N -acetyl- p -quinoneimine (NAPQI), a postulated toxic intermediate of acetaminophen metabolism, in mouse liver microsomal incubations is reported and is moderately stable at physiological pH and temperature with a lifetime which is dependent on the components of the medium. Expand
A reversed-phase high-performance liquid chromatographic method for characterization of biosynthetic human growth hormone.
TLDR
An isocratic reversed-phase high-performance liquid chromatographic method for the determination of human growth hormone (HGH) purity is described, which offers superior resolution of HGH-related substances from unmodified HGH when compared to a number of alternative Chromatographic and electrophoretic techniques. Expand
Evaluation of amino acid analysis as reference method to quantitate highly purified proteins.
TLDR
It is concluded that amino acid analysis is an appropriate reference method only when stable residues are employed for quantitation, particularly for highly purified proteins of rDNA origin. Expand
Trace determination of acetaminophen in serum.
TLDR
A simple and accurate method for measuring acetaminophen in serum was developed using liquid chromatography with electrochemical detection using N-propionyl-p-aminophenol. Expand
Determination of moxalactam in human body fluids by liquid chromatographic and microbiological methods
TLDR
Both types of assays were used in a study of the stability of moxalactam-containing samples at various temperatures and the precision and accuracy of the high-performance liquid chromatographic methods were superior. Expand
HPLC determination of D and L moxalactam in human serum and urine.
TLDR
The procedure was evaluated in a clinical setting to demonstrate its applicability to the study of moxalactam pharmacokinetics in critically ill patients and preliminary stability studies were performed to assess proper sample handling and storage conditions. Expand
Practical aspects of LC/EC determinations of pharmaceuticals in biological media
Abstract Liquid chromatography with electrochemical detection (LC/EC) has proven itself to be a very useful technique for the determination of electrochemically oxidizable or reducible compounds inExpand
A Universal HPLC Determination of Insulin Potency
Abstract A liquid chromatographic method for determination of insulin potency is presented. It is applicable to bovine, porcine and human insulins, and to both insulin crystals and insulinExpand
Liquid-chromatographic determination of penbutolol and its principal metabolites in plasma and urine.
TLDR
A sensitive, specific liquid-chromatographic determination of penbutolol and its 4-hydroxy metabolite in plasma and urine is described and is reproducible and nearly free of interferences. Expand
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