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A major role for VCAM-1, but not ICAM-1, in early atherosclerosis.
VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed inExpand
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PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.
The process of adipogenesis is known to involve the interplay of several transcription factors. Activation of one of these factors, the nuclear hormone receptor PPAR gamma, is known to promote fatExpand
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PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Abstract The process of adipogenesis is known to involve the interplay of several transcription factors. Activation of one of these factors, the nuclear hormone receptor PPARγ, is known to promoteExpand
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The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), the transcription factor target of the anti-diabetic thiazolidinedione (TZD) drugs, is reported to mediate macrophage differentiationExpand
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Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice
Peroxisome proliferator–activated receptor (PPAR)-γ is required for adipogenesis but is also found in the cardiovascular system, where it has been proposed to oppose inflammatory pathways and act asExpand
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The role of PPAR-γ in macrophage differentiation and cholesterol uptake
Peroxisome proliferator-activated receptor-γ (PPAR-γ), the transcription factor target of the anti-diabetic thiazolidinedione (TZD) drugs, is reported to mediate macrophage differentiation andExpand
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PPARγ Regulates Trophoblast Proliferation and Promotes Labyrinthine Trilineage Differentiation
Background Abnormal trophoblast differentiation and function is the basis of many placenta-based pregnancy disorders, including pre-eclampsia and fetal growth restriction. PPARγ, a ligand-activatedExpand
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Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice.
Muscarinic receptor-mediated cardiac parasympathetic activity is essential for regulating heart rate and heart rate variability (HRV). It has not been clear which G(i)/G(o) protein is responsible forExpand
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Activation-dependent isolation and culture of murine pulmonary microvascular endothelium.
OBJECTIVE Establish a reproducible method for the isolation and cultivation of murine pulmonary microvascular endothelium. To this end, we exploited the localized pattern of microvascular endothelialExpand
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Impaired activation of murine platelets lacking G alpha(i2).
The intracellular signaling pathways by which G protein-coupled receptors on the platelet surface initiate aggregation, a critical process for hemostasis and thrombosis, are not well understood. InExpand
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