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- Influence
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.
- H. Nagata, A. Worobec, +4 authors D. Metcalfe
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 7 November 1995
Both stem cells and mast cells express c-kit and proliferate after exposure to c-kit ligand. Mutations in c-kit may enhance or interfere with the ability of c-kit receptor to initiate the… Expand
Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis.
- B. Longley, D. Metcalfe, +5 authors Y. Ma
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 16 February 1999
Human mastocytosis is characterized by increased mast cells. It usually occurs as a sporadic disease that is often transient and limited in children and persistent or progressive in adults. The c-KIT… Expand
The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis.
- L. Schwartz, K. Sakai, +4 authors D. Metcalfe
- Chemistry, Medicine
- The Journal of clinical investigation
- 1 December 1995
Tryptase, a protease produced by all mast cells, was evaluated as a clinical marker of systemic mastocytosis. Two sandwich immunoassays were evaluated, one which used the mAb G5 for capture, the… Expand
Clinical correlates of the presence of the asp816Val c‐kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis
- A. Worobec, T. Semere, H. Nagata, D. Metcalfe
- Medicine
- Cancer
- 15 November 1998
The Asp816Val mutation in the catalytic domain of the c‐kit receptor has been identified in patients with systemic mastocytosis.
Clinical correlates of blood serotonin levels in patients with mastocytosis
- N. Kushnir-Sukhov, E. Brittain, L. Scott, D. Metcalfe
- Medicine
- European journal of clinical investigation
- 1 December 2008
Background Mastocytosis is a clonal disorder associated with an increased mast cell burden. We have recently demonstrated the ability of human mast cells to express and be activated through multiple… Expand
Elevated expression of the proto-oncogene c-kit in patients with mastocytosis
- H. Nagata, AS Worobec, T. Semere, D. Metcalfe
- Biology, Medicine
- Leukemia
- 1 February 1998
The stem cell factor (SCF)c-kit receptor interaction plays a critical role in the development and survival of mast cells. Several studies have also associated c-kit receptor mutations with the human… Expand