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BRL 17421 , a Novel f ,-Lactam Antibiotic , Highly Resistant to , 8-Lactamases , Giving High and Prolonged Serum Levels in Humans
The compound exhibits exceptional stability to a wide range of bacterial /8-lactamases and is active against the majority of Enterobacteriaceae, including strains highly resistant to many of the penicillins and cephalosporins currently available.
Effect of protein binding on antibiotic activity in vivo.
Using a group of penicillins all belonging to the same chemical class, antibacterial activity against Staphylococcus aureus was determined in vitro and also in vivo by use of an intraperitoneal
BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans
The compound was well tolerated after intramuscular and intravenous administration in volunteers, with no adverse side effects, and was markedly less active against Pseudomonas aeruginosa and Bacteroides fragilis than against the Enterobacteriaceae.
Activities and sources of beta-lactamase in sputum from patients with bronchiectasis
Sources of sputum beta-lactamases are often bacteria not considered truly pathogenic or not isolated during routine bacteriological assessment, and should be considered when embarking on antimicrobial therapy in bronchiectatic patients.
Use of pyocin 78-C2 in the treatment of Pseudomonas aeruginosa infection in mice.
Purified pyocin, administered parenterally to mice infected with sensitive strains of Pseudomonas aeruginosa, afforded significant protection against two of the three strains studied.
Variability of pyocine type and pyocine sensitivity in some strains of Pseudomonas aeruginosa.
Summary: In a study of pyocine typing of 274 strains of Pseudomonas aeruginosa isolated from the same hospital, evidence of instability in 2 pyocine indicator strains and in the pyocine type of 19%
A direct turbidimetric assay of pyocine.
An assay of pyocine based on the turbidimetric measurement of the percentage inhibition of a sensitive indicator strain of Pseudomonas aeruginosa is described which is simple, rapid in performance and has good precision and reproducibility.
A new multiple inoculator for bacteriocine typing.
A new design of multiple inoculator for bacteriocine typing that permits more certain sterilization than previous designs, which are briefly reviewed.
Guidelines for the welfare of animals in rodent protection tests: A Report from the Rodent Protection Test Working Party
These Guidelines recommend refinements to the RPT which reduce animal use to a minimum and suggest cardinal clinical signs which act as predictors of lethality.