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N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.
TLDR
It is concluded that NADAs, and AA-DA in particular, may be novel and useful probes for the study of the ECS. Expand
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action
TLDR
Research carried out in the past six years has confirmed a similarity between the endocannabinoids and the psychoactive substance in marijuana, delta9(-)-tetrahydrocannabinol, and suggested a role for endoc cannabinoidoids in the modulation of neurotransmitter action and release. Expand
Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes*
TLDR
The finding of biosynthetic and inactivating mechanisms for AnNH and PEA in macrophages and basophils supports the previously proposed role as local modulators of immune/inflammatory reactions for these two long chain acylethanolamides. Expand
Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells.
TLDR
The results suggest that the Ca2+-induced formation of 2-AG proceeds through the intermediacy of AcAGs but not necessarily through phospholipase C activation, and supports the hypothesis that this cannabimimetic monoacylglycerol might be a physiological neuromodulator. Expand
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation.
TLDR
The findings suggest that endogenous cannabinoids and CB1 receptor agonists are potential negative effectors of PRL- and NGF-induced biological responses, at least in some cancer cells. Expand
Involvement of the cAMP/protein kinase A pathway and of mitogen‐activated protein kinase in the anti‐proliferative effects of anandamide in human breast cancer cells
TLDR
Findings indicate that, in MCF‐7 cells, ANA inhibits adenylyl cyclase and activates MAPK, thereby exerting a down‐regulation on PRLr and trk levels and a suppression of cell proliferation. Expand
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.
TLDR
The data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous Prolactin action at the level of prolactin receptor. Expand
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.
TLDR
AA-5-HT is the first FAAH inhibitor reported to date which is inactive both against cPLA2 and at CB1 receptors, whereas AEG represents a new type of cannabinoid receptor agonist. Expand
Phosphatidic Acid as the Biosynthetic Precursor of the Endocannabinoid 2‐Arachidonoylglycerol in Intact Mouse Neuroblastoma Cells Stimulated with Ionomycin
TLDR
Data indicate that DAG precursors for 2‐AG in intact N18TG2 cells are obtained from the hydrolysis of PA and not through the activation of PLC, which would indicate that the PA‐dependent pathways of 2‐ AG formation are avoided. Expand
Interactions between synthetic vanilloids and the endogenous cannabinoid system
TLDR
It is reported that olvanil is a stable and potent inhibitor of AEA facilitated transport into rat basophilic leukemia (RBL‐2H3) cells, and some of the analgesic actions of olivanil may be due to its interactions with the endogenous cannabinoid system, and may lead to the design of a novel class of cannabimimetics with potential therapeutic applications as analgesics. Expand
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