• Publications
  • Influence
Characterization of rofecoxib as a cyclooxygenase‐2 isoform inhibitor and demonstration of analgesia in the dental pain model
Nonsteroidal anti‐inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and indomethacin (INN, indometacin) inhibit both the constitutive (COX‐1) and inducible (COX‐2) isoforms of cyclooxygenase.Expand
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Intranasal ketorolac for pain secondary to third molar impaction surgery: a randomized, double-blind, placebo-controlled trial.
PURPOSE This randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of intranasal (IN) ketorolac in patients who had third molar extraction surgery with bony impactions.Expand
  • 31
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The efficacy of combination analgesic therapy in relieving dental pain.
  • D. Mehlisch
  • Medicine
  • Journal of the American Dental Association
  • 1 July 2002
BACKGROUND An experience of poorly managed pain related to dental treatment can lead patients to avoid or postpone treatment. The development of new pain management strategies equips dentalExpand
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Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain.
This single-dose, double-blind, parallel-group, single-site study compared ibuprofen lysine 400 mg with acetaminophen 1000 mg and placebo in 240 patients with moderate-to-severe postoperative dentalExpand
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Ameloblastoma: a clinicopathologic report.
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Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents
BACKGROUND Combination analgesics may offer improved analgesic efficacy, particularly for moderate to severe pain. OBJECTIVE This study evaluated the analgesic benefits of concurrent ibuprofen andExpand
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The optimal analgesic dose of rofecoxib: Overview of six randomized controlled trials.
BACKGROUND Rofecoxib, which specifically inhibits cyclooxygenase-2, is indicated for relief of the signs and symptoms of osteoarthritis and for the management of acute pain in adults. The authorsExpand
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Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery.
PURPOSE Our goal was to compare the analgesic efficacy and safety of single doses of intravenous parecoxib sodium, a prodrug of the novel cyclooxygenase (COX)-2-selective inhibitor valdecoxib, withExpand
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Ketoprofen, Acetaminophen, and Placebo in the Treatment of Tension Headache
Seven hundred three subjects completed a randomized, double‐blind, parallel‐group, single‐center study comparing the single‐dose efficacy of ketoprofen 12.5 mg, ketoprofen 25 mg, acetaminophen 1000Expand
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Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain.
Pharmacological management of pain for acute and chronic conditions has been guided by a scientific understanding of peripheral and central acting mechanisms for the control of inflammation as wellExpand
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