• Publications
  • Influence
Posttranslational modification of p53: cooperative integrators of function.
  • D. Meek, C. Anderson
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 1 December 2009
The p53 protein is modified by as many as 50 individual posttranslational modifications. Many of these occur in response to genotoxic or nongenotoxic stresses and show interdependence, such that oneExpand
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Regulation of the specific DNA binding function of p53
The DNA binding activity of p53 is required for its tumor suppressor function; we show here that this activity is cryptic but can be activated by cellular factors acting on a C-terminal regulatoryExpand
  • 899
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Tumour suppression by p53: a role for the DNA damage response?
  • D. Meek
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 October 2009
Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptoticExpand
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  • PDF
The p53 response to DNA damage.
  • D. Meek
  • Biology, Medicine
  • DNA repair
  • 1 August 2004
The p53 tumour suppressor protein is a highly potent transcription factor which, under normal circumstances, is maintained at low levels through the action of MDM2, an E3 ubiquitin ligase whichExpand
  • 366
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Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
The p53 tumour suppressor protein is a labile transcription factor that is activated and stabilized in response to a wide range of cellular stresses, through a mechanism involving disruption of itsExpand
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Posttranslational modification of MDM2.
The functions of the MDM2 protein, in particular its E3 ubiquitin ligase activity and its ability to interact with a number of cellular proteins intimately involved in growth regulation, areExpand
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Regulation of the p53 response and its relationship to cancer.
  • D. Meek
  • Biology, Medicine
  • The Biochemical journal
  • 1 August 2015
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cancer cells and eliminates them through senescence (a permanent non-proliferative state) or apoptosis.Expand
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p53 Represses Cyclin D1 Transcription through Down Regulation of Bcl-3 and Inducing Increased Association of the p52 NF-κB Subunit with Histone Deacetylase 1
ABSTRACT The p53 and NF-κB transcription factor families are important, multifunctional regulators of the cellular response to stress. Here we have investigated the regulatory mechanisms controllingExpand
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Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters
The p53 tumour suppressor is induced by various stress stimuli and coordinates an adaptive gene expression programme leading to growth arrest or cell death. Some stimuli, such as DNA damage, lead toExpand
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Mechanisms of switching on p53: a role for covalent modification?
  • D. Meek
  • Biology, Medicine
  • Oncogene
  • 13 December 1999
The p53 protein plays a pivotal role in activating and integrating adaptive cellular responses to a wide range of environmental stresses. Activation of p53 can occur by different molecular routes,Expand
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