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Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.

TLDR
It is found that PGC-1 gene expression is induced in the mouse heart after birth and in response to short-term fasting, conditions known to increase cardiac mitochondrial energy production.
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Dietary Reference Intakes: the Essential Guide to Nutrient Requirements edited by JJ Otten, JP Hellwig, and LD Meyers, 2006, 560 pages, hardcover, $44.96. The National Academies Press, Washington, DC.

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PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

TLDR
It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.
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Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.

TLDR
It is concluded that P GC-1alpha and PGC-1beta share roles that collectively are necessary for the postnatal metabolic and functional maturation of heart and BAT.
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Advanced Human Nutrition

Advanced Human Nutrition, Second Edition provides an in-depth overview of the human body and details why nutrients are important from a biochemical, physiological, and molecular perspective. Figures…
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Cardiac-Specific Induction of the Transcriptional Coactivator Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1&agr; Promotes Mitochondrial Biogenesis and Reversible Cardiomyopathy in a…

TLDR
Results indicate that PGC-1&agr; drives mitochondrial biogenesis in a developmental stage-dependent manner permissive during the neonatal period, and this unique murine model should prove useful for the study of the molecular regulatory programs governing mitochondrialBiogenesis.
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Assessing mitochondria biogenesis.

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A Unified Perspective on Copper Deficiency and Cardiomyopathy

TLDR
A hypothetical working model explaining the events leading to cardiac failure in the copper-deficient rat heart is presented based on the present body of knowledge, and the pathology is compared with other models of cardiomyopathies.
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Zinc supplements and serum lipids in young adult white males.

TLDR
Serum total cholesterol, low-density-lipoprotein (LDL) cholesterol, very-low- density- Lipoprotein-cholesterol fractions, and serum triglycerides were not affected by Zn supplements, however, serum high-density -cholesterol levels in subjects assigned to the 75 mg Zn/d group were significantly lower at weeks 6 and 12 than those for the placebo group.
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Myofibrillar, mitochondrial and valvular morphological alterations in cardiac hypertrophy among copper-deficient rats.

TLDR
There are two components contributing to cardiac hypertrophy in copper deficient rats: 1) an enlarged mitochondrial area and 2) myofibrillar enlargement.
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