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- Publications
- Influence
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.
- J. J. Lehman, P. Barger, A. Kovács, J. Saffitz, D. Medeiros, D. Kelly
- Biology, Medicine
- The Journal of clinical investigation
- 1 October 2000
Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. Recent studies have identified the transcriptional coactivator peroxisome… Expand
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
- T. Leone, J. J. Lehman, +15 authors D. Kelly
- Biology, Medicine
- PLoS biology
- 15 March 2005
The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was targeted in mice. PGC-1α null (PGC-1α−/−) mice were viable. However,… Expand
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.
Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to meet the high-energy demands after birth. PPARgamma coactivator-1 (PGC-1) alpha and beta have been implicated… Expand
Cardiac-Specific Induction of the Transcriptional Coactivator Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1&agr; Promotes Mitochondrial Biogenesis and Reversible Cardiomyopathy in a…
- Laurie K. Russell, C. M. Mansfield, +7 authors D. Kelly
- Biology, Medicine
- Circulation research
- 5 March 2004
Abstract— Recent evidence has identified the peroxisome proliferator-activated receptor &ggr; coactivator-1&agr; (PGC-1&agr;) as a regulator of cardiac energy metabolism and mitochondrial biogenesis.… Expand
A Unified Perspective on Copper Deficiency and Cardiomyopathy
- D. Medeiros, J. Davidson, J. E. Jenkins
- Biology, Medicine
- Proceedings of the Society for Experimental…
- 1 July 1993
Abstract Dietary copper restriction in rats results in cardiomyopathy. In rats fed copper-restricted diets from weaning for 5 to 8 weeks, a concentric hypertrophy is apparent, whereas postweaning… Expand
Zinc supplements and serum lipids in young adult white males.
- M. R. Black, D. Medeiros, E. Brunett, R. Welke
- Chemistry, Medicine
- The American journal of clinical nutrition
- 1 June 1988
A 12-wk double-blind study was conducted to determine the effect of oral zinc supplementation upon serum total cholesterol, lipoprotein-cholesterol fractions, and serum triglycerides in white males.… Expand
Myofibrillar, mitochondrial and valvular morphological alterations in cardiac hypertrophy among copper-deficient rats.
- D. Medeiros, D. Bagby, G. Ovecka, R. Mccormick
- Biology, Medicine
- The Journal of nutrition
- 1 June 1991
Histological aspects of Cu-deficient hypertrophied rat hearts were evaluated to determine causal factors. Twenty-four male weanling rats were fed either Cu-adequate (8.0 mg/kg diet) or Cu-deficient… Expand
Assessing mitochondria biogenesis.
- D. Medeiros
- Biology, Medicine
- Methods
- 1 December 2008
Mitochondria have their own DNA (mtDNA) and hence biogenesis of mitochondria requires a coordination of nuclear and mtDNA, both of which encode for mitochondria proteins. Our understanding of the… Expand
Oxidative stress-induced apoptosis of endothelial cells.
- M. Warren, E. Bump, D. Medeiros, S. Braunhut
- Biology, Medicine
- Free radical biology & medicine
- 15 September 2000
Endothelial cells (ECs) are subjected to oxidative stress during many pathological processes, including ischemia/reperfusion and general inflammation. In the present study, we examined the effects of… Expand
Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor-&agr;/PGC-1&agr; Gene Regulatory Pathway
- J. Duncan, Juliet L. Fong, D. Medeiros, B. Finck, D. Kelly
- Biology, Medicine
- Circulation
- 20 February 2007
Background— Obesity and diabetes mellitus are complex metabolic problems of pandemic proportion, contributing to significant cardiovascular mortality. Recent studies have shown altered mitochondrial… Expand