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Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca.
The levels of DMT and beta-carbolines found in the ayahuasca samples examined in the present study were an order of magnitude greater than the levels reported in a previous study, which indicated that their effects in combination are additive, rather than synergistic or antagonistic. Expand
Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges.
  • D. Mckenna
  • Political Science, Chemistry
  • Pharmacology & therapeutics
  • 1 May 2004
Because of ayahuasca's ill-defined legal status and variable botanical and chemical composition, clinical investigations in the United States, ideally under an approved Investigational New Drug (IND) protocol, are complicated by both regulatory and methodological issues. Expand
Pharmacokinetics of Hoasca alkaloids in healthy humans.
N,N-Dimethyltryptamine, harmine, harmaline and tetrahydroharmine are the characteristic alkaloids found in Amazonian sacraments known as hoasca, ayahuasca, and yajè and little is known of their pharmacokinetics. Expand
Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.
The one-step extraction method for DMT and the protein precipitation method for the three harmala alkaloid afford rapid, sensitive, and quantitative analyses of these alkaloids with minimal analyte loss. Expand
Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes
It is demonstrated that hallucinogenic 4-hydroxy-indolealkylamine derivatives, like psychotomimetic phenylisopropylamines, bind potently and selectively to the 5-HT2A recognition site, labelled by [125I]R-(-)DOI. Expand
Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications.
Ginkgo biloba is a dioecious tree with a history of use in traditional Chinese medicine. Although the seeds are most commonly employed in traditional Chinese medicine, in recent years standardizedExpand
Botanical Medicines: The Desk Reference for Major Herbal Supplements
This Desk Reference discusses Dietary Supplements, a large variety of herbs and plants used in herbal remedies for pregnancy, lactation, and Pediatrics, as well as some of their applications in clinical practice. Expand
The Scientific Investigation of Ayahuasca: A Review of Past and Current Research
Of the numerous plant psychotropics utilized by indigenous populations of the Amazon Basin, perhaps none is as interesting or complex, botanically, chemically, or ethnographically, as the beverageExpand
Neurochemistry and Neurotoxicity of 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
The following review attempts to provide a brief summary of recent data on the neurochemistry and neurotoxicity of MDMA and its derivatives. Expand
3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine
In the neurotoxicity study of the compounds investigated, only (+)MDA caused a significant loss of 5-HT uptake sites in comparison to saline-treated controls, and their possible relevance to neurotoxicity in this series of MDA congeners is discussed. Expand