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A permanent change in brain function resulting from daily electrical stimulation.
TLDR
High-intensity stimulation studies revealed that the development of convulsions was not based simply on threshold reduction, but involved complex reorganization of function.
Kindling: basic mechanisms and clinical validity.
Kindling: some old and some new
TLDR
The recent attempt to discover consistent and unique gene profile differences associated with the different seizure predispositions of the Fast and Slow kindling rat strains indicated substantial strain differences in GABAergic function in different limbic structures associated with GABA(A) subunit expression.
Hippocampal kindling protects several structures from the neuronal damage resulting from kainic acid-induced status epilepticus
TLDR
Although the mechanism(s) of this kindling-based neuroprotection is not known, its discovery should add importantly to the understanding of epilepsy-induced alterations of subsequent neuronal function.
Development of kindling-prone and kindling-resistant rats: selective breeding and electrophysiological studies
TLDR
These strains should provide many clues to the dispositional differences between individuals for the development of epilepsy originating in temporal lobe structures.
Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus
TLDR
It is demonstrated that CA1 neuronal loss induced by 4-VO is preceded by a selective and marked elevation of catalytically active caspase-3 in these neurons, indicative of apoptosis, and that blockade of this event by XIAP overexpression permits CA1 neurons to survive and operate properly after an ischemic insult.
Efferent projections of the anterior perirhinal cortex in the rat
TLDR
Because convulsive seizures develop very rapidly from kindling sites in the anterior perirhinal cortex, the anterograde tracer Phaseolus vulgaris leucoagglutinin (PhAL) was studied to determine that layer V was the main source of the perirhinofrontal projection.
Kindling in the perirhinal cortex
TLDR
The relationship of kindling rate and convulsion latencies and durations between the 4 structures was discussed and it was observed that the after-discharge threshold of the perirhinal cortex was higher than the other 3 structures but the AD duration was not different.
Mapping seizure pathways in the temporal lobe
TLDR
The network structures in the temporal lobe that are recruited in animal models during various forms of limbic seizures and status epilepticus are described, common to all of the various models is recruitment of the parahippocampal cortices.
FAST and SLOW amygdala kindling rat strains: comparison of amygdala, hippocampal, piriform and perirhinal cortex kindling
TLDR
Compared the local excitability, kindling rates, and convulsion profiles of kindling sites in either the amygdala, dorsal hippocampus, piriform cortex or perirhinal cortex in the two strains, a selection bias for the amygdala and its networks was suggested.
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