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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.
  • D. McRee
  • Computer Science, Medicine
    Journal of structural biology
  • 1 April 1999
Xfit is a model-building and map viewing program in XtalView that is used by the structural biology community including researchers in the fields of crystallography, molecular modeling, and electron
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
The first crystal structures of a humanHDAC are described: the structures of human HDAC8 complexed with four structurally diverse hydroxamate inhibitors, which sheds light on the catalytic mechanism of the HDACs, and on differences in substrate specificity across theHDAC family.
Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.
The first structure of a mammalian microsomal P450 suggests that the association of P450s with the endoplasmic reticulum involves a hydrophobic surface of the protein formed by noncontiguous portions of the polypeptide chain.
Practical Protein Crystallography
Laboratory Techniques: Preparing Protein Samples. Protein Crystal Growth. Crystal Storage and Handling. Crystal Soaking. Anaerobic Crystals. Data Collection Techniques: Preparing Crystals for Data
Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation*
The results provide key insights into the molecular basis for c-Kit kinase transactivation to assist in the design of new competitive inhibitors targeting activated mutant forms of c- Kit that are resistant to current chemotherapy regimes.
Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography
The atomic structure of the bleached signaling intermediate in the light cycle of PYP was determined by millisecond time-resolved, multiwavelength Laue crystallography and simultaneous optical spectroscopy to suggest a general framework for the interpretation of protein photocycles.
Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.
The crystal structure of the DNA repair enzyme endonuclease III reveals an unusual fold and a new biological function for [4Fe-4S] clusters and provides a structural basis for studying recognition of damaged DNA and the N-glycosylase and apurinic/apyrimidinic-lyase mechanisms.
Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38
The crystal structure provides a model for two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize cADPR and Cyclase contains two spatially separated pockets composed of sequence conserved residues, suggesting that the cyclization reaction may entail use of distinct sites.
Self-assembling organic nanotubes based on a cyclic peptide architecture
Nature 366, 324-327(1993) IN this Letter important references to earlier works were inadvertently left out. De Santis et aL, in the context of a theoretical conformational analysis of linear regular