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A Novel Sialic Acid Binding Site on Factor H Mediates Serum Resistance of Sialylated Neisseria gonorrhoeae
TLDR
Functional specificity of fH was confirmed by decreased total C3 binding and almost complete conversion to iC3b on sialylated gonococci, and sialic acid can bind fH uniquely through SCRs 16–20, which blocks complement pathway activation for N. gonorrhoeae at the level of C3. Expand
Fecal Microbiota Transplant for Treatment of Clostridium difficile Infection in Immunocompromised Patients
TLDR
This series demonstrates the effective use of FMT for CDI in IC patients with few SAEs or related AEs, and there were no related infectious complications in these high-risk patients. Expand
Emerging Cases of Powassan Virus Encephalitis in New England: Clinical Presentation, Imaging, and Review of the Literature.
TLDR
8 cases of POWV encephalitis in Massachusetts and New Hampshire in 2013-2015 are described to represent emergence of this virus in a region where its vector, I. scapularis, is known to be prevalent or may represent the emerging diagnosis of an underappreciated pathogen. Expand
Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae
We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-bindingExpand
The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.
TLDR
Meningococcal strains with Class 3 Por preferentially bind factor H, suggesting Class 2 Por acts as a receptor for factor H and Porin is also instrumental in mediating stable serum resistance in gonococci. Expand
Binding of Complement Factor H to Loop 5 of Porin Protein 1A: A Molecular Mechanism of Serum Resistance of Nonsialylated Neisseria gonorrhoeae
TLDR
It is demonstrated that Por1A bearing gonococcal strains bind more factor H, a critical downregulator of the alternative complement pathway, than their Por1B counterparts, which results in a sevenfold reduction in C3b, which is >75% converted to iC3b. Expand
Binding of Complement Factor H to Loop 5 of Porin Protein 1A: A Molecular Mechanism of Serum Resistance of Nonsialylated Neisseria gonorrhoeae
TLDR
It is demonstrated that Por1A bearing gonococcal strains bind more factor H, a critical downregulator of the alternative complement pathway, than their Por1B counterparts, which results in a sevenfold reduction in C3b, which is >75% converted to iC3b. Expand
Immunogenicity of Neisseria gonorrhoeae lipooligosaccharide epitope 2C7, widely expressed in vivo with no immunochemical similarity to human glycosphingolipids.
TLDR
The gonococcal lipooligosaccharide epitope identified by MAb 2C7 may represent an excellent target for a potentially protective Gonococcal vaccine candidate. Expand
Infectious diseases specialty intervention is associated with decreased mortality and lower healthcare costs.
TLDR
Patients receiving ID intervention within 2 days of admission had significantly lower 30-day mortality and readmission, hospital and ICU length of stay, and Medicare charges and payments compared with patients receiving later ID interventions. Expand
Functional characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae.
TLDR
A JB1 variant expressing the invasion-associated Opa protein was as able to enter Chang human conjunctiva epithelial cells as an OpA-positive variant of F62, suggesting that the sialyltransferase is not required for Opa-mediated entry. Expand
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