Rhenium-188-HEDP-kit Formulation and Quality Control
- E. S. Verdera, J. Gaudiano, F. Knapp
- Medicine, Biology
Re-HEDP has been prepared from lyophilized kits with Re from the alumina W/Re generator for evaluation for potential, cost-effective pain relief for patients with bone metastases and demonstrated rapid bone uptake, blood clearance, and high renal excretion with negligible liver and thyroid activity.
Effects of configuration on the myocardial uptake of radioiodinated 3(R)-BMIPP and 3(S)-BMIPP in rats.
It is suggested that [(123)I]-3(R)-BMIPP is a candidate for clinical evaluation and may show greater myocardial uptake than the 3(S)- BMIPP isomer and may thus require reduced injected dose.
In vivo competition studies of Z-(-,-)-[125I]IQNP against 3-quinuclidinyl 2-(5-bromothienyl)-2-thienylglycolate (BrQNT) demonstrating in vivo m2 muscarinic subtype selectivity for BrQNT
- V. I. Cohen, B. R. Zeeberg, R. C. Reba
- Biology, ChemistryJournal of Molecular Neuroscience
- 1 August 1998
It is concluded that BrQNT is m2-selective in vivo, and that [76Br]BrQNT, or a radiofluorinated analog, may be of potential use in positron emission tomographic (PET) study of the loss of m2 receptors in AD.
The formation of amino acid precursors in the reaction of atomic carbon with water and ammonia at 77 K
- D. McPherson, K. Rahman, I. Martínez, Philip B. Shevlin
- ChemistryOrigins of life and evolution of the biosphere
It is postulated that these reactions may mimic those which occur when an extraterrestrial carbon atom condenses on a frozen surface coated with water and ammonia and may provide a route to extraterrestrial amino acids.
Nuclear medicine program progress report for quarter ending December 31, 1996
- F. Knapp, A. Beets, R. Boll, H. Luo, D. McPherson, S. Mirzadeh
- 20 March 1997
Further studies with the E-(R,R)-IQNP ligand developed in the ORNL Nuclear Medicine Program are described as a potential imaging agent for detection of changes which may occur in the cerebral muscarinic-cholinergic receptors (mAChR) in Alzheimer`s and other diseases.
Characterization of in vivo brain muscarinic acetylcholine receptor subtype selectivity by competition studies against (R,S)-[125I]IQNB (Brain Res. 687 (1995) 71–78) BRES 11314)
[18F]-N-Methylspiroperidol: the radioligand of choice for PETT studies of the dopamine receptor in human brain.
- C. Arnett, J. Fowler, A. Wolf, C. Shiue, D. McPherson
- Biology, ChemistryLife Science
- 8 April 1985
No-carrier-added fluorine-18-labeled N-methylspiroperidol: synthesis and biodistribution in mice.
- C. Shiue, J. Fowler, A. Wolf, D. McPherson, C. Arnett, L. Zecca
- ChemistryJournal of Nuclear Medicine
- 1 February 1986
No-carrier-added fluorine-18- (18F) labeled N-methylspiroperidol was synthesized from four different substrates using the nucleophilic aromatic substitution reaction and maximizes product specific activity and experimental simplicity and provides 4 in 10-15% radiochemical yield.
Synthesis and antimuscarinic activity of some 1-cycloalkyl-1-hydroxy-1-phenyl-3-(4-substituted piperazinyl)-2-propanones and related compounds.
- C. Kaiser, V. H. Audia, L. Noronha-Blob
- Chemistry, BiologyJournal of Medicinal Chemistry
- 5 March 1993
Results of this study are consistent with the proposition that the described piperazinylpropanones interact with muscarcinic receptors in a hydrogen-bonded form that presents a conformation similar to that apparently adopted by classical antimuscarinic agents.
Serial PET studies of human cerebral malignancy with [1-11C]putrescine and [1-11C]2-deoxy-D-glucose.
- E. Hiesiger, J. Fowler, E. Flamm
- Medicine, BiologyJournal of Nuclear Medicine
- 1 August 1987
PET studies with [11C]PUT provide a better signal:noise ratio than GMR measurements, are useful for locating small glycolytically hypometabolic tumors and, when used in longitudinal studies in a single subject, appear to provide an index of degree of malignancy.