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MERLIN observations of relativistic ejections from GRS 1915+105
We present high resolution MERLIN radio images of multiple relativistic ejections from GRS 1915+105 in 1997 October / November. The observations were made at a time of complex radio behaviour,… Expand
Relativistic motion in a nearby bright X-ray source
THE recent discovery1 of radio components apparently moving away from a Galactic source of transient X-ray emission faster than the speed of light (superluminal motion) has identified a low-energy… Expand
Direct integration of Hox and segmentation gene inputs during Drosophila development
During Drosophila embryogenesis, segments, each with an anterior and posterior compartment, are generated by the segmentation genes while the Hox genes provide each segment with a unique identity.… Expand
Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryo.
- Katharine N Schulz, Eliana R. Bondra, +5 authors M. Harrison
- Biology, Medicine
- Genome research
- 2 September 2015
The transition from a specified germ cell to a population of pluripotent cells occurs rapidly following fertilization. During this developmental transition, the zygotic genome is largely… Expand
A common set of DNA regulatory elements shapes Drosophila appendages.
Animals have body parts made of similar cell types located at different axial positions, such as limbs. The identity and distinct morphology of each structure is often specified by the activity of… Expand
Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAFV600E mutation
BRAFV600E mutations are found in 10% of colorectal cancers (CRCs). The low frequency of this mutation therefore makes it a challenging target for drug development, unless subsets of patients with… Expand
Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax.
The homothorax (hth) gene of Drosophila melanogaster is required for executing Hox functions, for head development, and for forming the proximodistal (PD) axis of the appendages. We show that… Expand
Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development.
The development of the Drosophila leg requires both Decapentaplegic (Dpp) and Wingless (Wg), two signals that establish the proximo-distal (PD) axis by activating target genes such as Distalless… Expand
Transcription factors mediate long-range enhancer–promoter interactions
- Ilias K Nolis, D. McKay, Eva Mantouvalou, S. Lomvardas, Menie Merika, D. Thanos
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 1 December 2009
We examined how remote enhancers establish physical communication with target promoters to activate gene transcription in response to environmental signals. Although the natural IFN-β enhancer is… Expand
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
- J. Gauthier, N. Chauret, +26 authors W. C. Black
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 February 2008
Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to address the metabolic liabilities of the Cat K inhibitor L-873724. Substituting P1 and modifying the P2… Expand