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Thalamocortical oscillations in the sleeping and aroused brain.
Analysis of cortical and thalamic networks at many levels, from molecules to single neurons to large neuronal assemblies, with a variety of techniques, is beginning to yield insights into the mechanisms of the generation, modulation, and function of brain oscillations. Expand
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex.
- D. McCormick, B. Connors, J. W. Lighthall, D. Prince
- Psychology, Medicine
- Journal of neurophysiology
- 1 October 1985
Slices of sensorimotor and anterior cingulate cortex from guinea pigs were maintained in vitro and bathed in a normal physiological medium, observing three distinct neuronal classes of electrophysiological behavior; these were regular spiking, bursting, and fast spiking. Expand
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
The results demonstrate that the cerebral cortex generates an ‘up’ or depolarized state through recurrent excitation that is regulated by inhibitory networks, thereby allowing local cortical circuits to enter into temporarily activated and self-maintained excitatory states. Expand
Turning on and off recurrent balanced cortical activity
It is shown that local cortical circuits do indeed operate through a proportional balance of excitation and inhibition generated through local recurrent connections, and that the operation of such circuits can generate self-sustaining activity that can be turned on and off by synaptic inputs. Expand
Sleep and arousal: thalamocortical mechanisms.
The release of several different neurotransmitters from the brain stem, hypothalamus, basal forebrain, and cerebral cortex results in a depolarization of thalamocortical and thalamic reticular neurons and an enhanced excitability in many cortical pyramidal cells, thereby suppressing the generation of sleep rhythms and promoting a state that is conducive to sensory processing and cognition. Expand
Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
- D. McCormick
- Biology, Medicine
- Progress in Neurobiology
- 1 October 1992
Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection
A cortical physiological signature of the classically observed inverted-U relationship between task performance and arousal is revealed and it is revealed that optimal detection exhibits enhanced sensory-evoked responses and reduced background synaptic activity. Expand
Properties of a hyperpolarization‐activated cation current and its role in rhythmic oscillation in thalamic relay neurones.
Results indicate that Ih is carried by both Na+ and K+ ions, which is consistent with the extrapolated reversal potential of ‐43 mV, and contributes substantially to the resting and active membrane properties of thalamocortical relay neurones. Expand
Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex
Chattering cells located in the superficial layers of the cortex intrinsically generate 20- to 70-hertz repetitive burst firing in response to suprathreshold depolarizing current injection, and exhibit pronounced oscillations in membrane potential during visual stimulation that are largely absent during periods of spontaneous activity. Expand
Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices.
- A. Destexhe, T. Bal, D. McCormick, T. Sejnowski
- Chemistry, Medicine
- Journal of neurophysiology
- 1 September 1996
Two key properties of cells in the thalamic network may account for the initiation, propagation, and termination of spindle oscillations, the activity-dependent upregulation of Ih in TC cells, and the localized axonal projections between TC and RE cells. Expand