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Sigma‐1 and Sigma‐2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns
Radioligand binding assay conditions were established for the selective labeling of sigma‐1 and sigma‐2 sites in membrane homogenates of rat brain. Selective sigma‐1 assays were conducted using 5 nMExpand
Medication Nonadherence, “Professional Subjects,” and Apparent Placebo Responders: Overlapping Challenges for Medications Development
Abstract Nonadherence is a major problem in clinical trials of new medications. To evaluate the extent of nonadherence, this study evaluated pharmacokinetic sampling from 1765 subjects receivingExpand
Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions.
  • D. McCann, T. Su
  • Biology, Medicine
  • European journal of pharmacology
  • 25 April 1990
The distribution of haloperidol-sensitive (+)[3H]N-allylnormetazocine ((+)[3H]SKF-10,047) binding sites (sigma sites) in subcellular fractions of rat brain homogenates was extensively characterized.Expand
Drugs of abuse: management of intoxication and antidotes.
Illicit drug intoxications are an increasing public health problem for which, in most cases, no antidotes are clinically available. The diagnosis and treatment of these intoxications requires aExpand
Phencyclidine/SKF-10,047 binding sites: Evaluation of function
Results of correlation analyses comparing rank-order affinities with rank-order potencies of (+)SKF-10,047, phencyclidine (PCP), and several PCP analogs support the involvement ofExpand
Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes.
  • D. McCann, T. Su
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 May 1991
The zwitterionic detergent 3-[(3-cholamidopropyl)dimethylamino]-1-propanesulfonate (CHAPS) produced optimal solubilization of (+)-[3H]SKF-10,047 binding sites from rat liver membranes at aExpand
Mitigating the Effects of Nonadherence in Clinical Trials
Accounting for subject nonadherence and eliminating inappropriate subjects in clinical trials are critical elements of a successful study. Nonadherence can increase variance, lower study power, andExpand
Potential of Buprenorphine/Naltrexone in Treating Polydrug Addiction and Co‐occurring Psychiatric Disorders
  • D. McCann
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1 April 2008
In recent years, we have seen regulatory approval being given for several new pharmacotherapies in the treatment of drug addiction disorders. Within the United States, the most noteworthy developmentExpand
Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys.
The effectiveness of methadone as a treatment for opioid abuse and nicotine preparations as treatments for tobacco smoking has led to an interest in developing a similar strategy for treatingExpand
Interactions of clonidine with phencyclidine and ketamine: Studies of radial maze performance and righting reflex in rats
Rats were trained to obtain food pellets in an 8-arm radial maze until a criterion of 89% efficiency, i.e., all arms entered within 9 arm entries, was reached in 5 consecutive sessions. Decreases inExpand