Aspartame: review of safety.
- H. Butchko, W. Stargel, F. Trefz
- BiologyRegulatory toxicology and pharmacology : RTP
- 1 April 2002
The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive, and there are no unresolved questions regarding its safety under conditions of intended use.
A possible role for the adenylcyclase system in insulin secretion.
- W. Malaisse, F. Malaisse-Lagae, D. Mayhew
- Biology, MedicineJournal of Clinical Investigation
- 1 November 1967
It is suggested that the beta-cell contains an adenylcyclase system through which phosphorylase and possibly phosphofructokinase could be activated; and that insulin secretion could depend upon and be regulated by hormones and other substances which influence the rate at which glycolysis proceeds within the Beta-cell.
Regulation of insulin secretion.
- D. Mayhew, P. Wright, J. Ashmore
- MedicinePharmacological Reviews
- 1 September 1969
Safety assessment of DHA-rich microalgae from Schizochytrium sp.
- B. Hammond, D. Mayhew, J. Holson, M. D. Nemec, R. Mast, W. J. Sander
- MedicineRegulatory toxicology and pharmacology : RTP
- 1 June 2001
Maternal exposure to DRM during organogenesis did not adversely affect the frequency of postimplantation loss, mean fetal body weight/litter, or external, visceral, or skeletal malformations in either the rat or the rabbit and developmental toxicity was not observed at any DRM dose level.
Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies.
- D. Mayhew, C. P. Comer, W. Stargel
- Biology, MedicineRegulatory toxicology and pharmacology : RTP
- 1 October 2003
Safety assessment of DHA-rich microalgae from Schizochytrium sp.
- B. Hammond, D. Mayhew, M. W. Naylor, F. Ruecker, R. Mast, W. J. Sander
- BiologyRegulatory toxicology and pharmacology : RTP
- 1 April 2002
Administration of DRM did not produce any treatment-related adverse effects in Sprague-Dawley rats of relevance to humans at dosages up to 4000 mg/kg/day for 13 weeks and a slight increase in the incidence, but not severity, of cardiomyopathy was observed.
Regulatory toxicology and pharmacology
- H. Butchko, W. Stargel, F. Trefz
- Biology
- 2 July 2002
Bioelution assays are fast, simple alternatives to in vivo testing, and in this study, the intra- and inter-labora trials showed good results for both in vitro and in vivo bioelution testing.
Absence of developmental effects in CF-1 mice exposed to aspartame in utero.
- P. Mcanulty, M. J. Collier, F. N. Kotsonis
- BiologyFundamental and Applied Toxicology
- 1 August 1989
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