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S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells.
S100 proteins, a multigenic family of calcium-binding proteins, have been linked to human pathologies in recent years. Deregulated expression of S100 proteins, including S100A8 and S100A9, wasExpand
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Down‐regulation of insulin‐like growth factor‐I receptor and insulin receptor substrate‐1 expression in advanced human breast cancer
The ligands, receptors and related signaling proteins of the insulin‐like growth factor family are involved in the regulation of breast‐cancer cell growth. We investigated the expression pattern ofExpand
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Glycogen Synthase Kinase-3 Interacts with and Phosphorylates Estrogen Receptor α and Is Involved in the Regulation of Receptor Activity*
Like other steroid hormone receptors, estrogen receptor-α (ERα) is a substrate for protein kinases, and phosphorylation has profound effects on the function and activity of this receptor. A number ofExpand
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Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer
Purpose: S100 proteins comprise a family of calcium-modulated proteins that have recently been associated with epithelial tumors. We examined the expression of two members of this family, S100A8 andExpand
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Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.
The insulin-like growth factors, IGF-I and IGF-II are a family of mitogenic polypeptides with important roles in growth and differentiation. The biological actions of the IGFs are mediated by theExpand
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Glycogen Synthase Kinase-3 Interacts with and Phosphorylates Estrogen Receptor and Is Involved in the
Like other steroid hormone receptors, estrogen receptor- (ER) is a substrate for protein kinases, and phosphorylation has profound effects on the function and activity of this receptor. A number ofExpand
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Proliferative effect of Apidra® (insulin glulisine), a rapid-acting insulin analogue on mammary epithelial cells
The structural modification of insulin results in the generation of insulin analogues that show altered binding affinities to the insulin receptor and/or the IGF-I receptor, and as a consequenceExpand
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Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer
AKT/PKB is a central signaling molecule related to stimulation of cell proliferation and inhibition of apoptosis. Perturbations of AKT expression and function play an important role in tumorExpand
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Sequential Appearance and Ultrastructure of Amphophilic Cell Foci, Adenomas, and Carcinomas in the Liver of Male and Female Rats Treated with Dehydroepiandrosterone
Dehydroepiandrosterone (DHEA), a hormone of the adrenal cortex, acts as a peroxisome proliferator and hepatocarcinogen in rats upon long-term treatment with high doses in the diet. The aim of theExpand
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Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patients
Prostate cancer is the most common cancer in men and second in the cancer-related frequency of mortality. Matrix metalloproteinases (MMPs) are involved in tumor invasion and metastasis in variousExpand
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