• Publications
  • Influence
Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?
The common neurotrophin receptor (p75NTR) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of theExpand
  • 78
  • 8
Characterization and use of the NSC‐34 cell line for study of neurotrophin receptor trafficking
This study addressed the suitability of the NSC‐34 cell line as a motor neuron‐like model for investigating neurotrophin receptor trafficking and associated subcellular processes. Initially, cultureExpand
  • 50
  • 3
The Human G93A-Superoxide Dismutase-1 Mutation, Mitochondrial Glutathione and Apoptotic Cell Death
Mutations in Cu/Zn superoxide dismutase are a cause of motor neuron death in about 20% of cases of familial amyotrophic lateral sclerosis (ALS). Although the molecular mechanism of which theseExpand
  • 34
  • 3
ProNGF mediates death of Natural Killer cells through activation of the p75NTR–sortilin complex
The common neurotrophin receptor P75NTR, its co-receptor sortilin and ligand proNGF, have not previously been investigated in Natural Killer (NK) cell function. We found freshly isolated NK cellsExpand
  • 43
  • 3
Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis*
Background: Sortilin and p75NTR induce neuronal apoptosis by binding pro-neurotrophins during development and following neuronal injury. Results: Sortilin interacts with an extracellularExpand
  • 41
  • 3
An Intracellular Domain Fragment of the p75 Neurotrophin Receptor (p75NTR) Enhances Tropomyosin Receptor Kinase A (TrkA) Receptor Function*
Background: The mechanism by which the p75 neurotrophin receptor (p75NTR) and TrkA interact to enhance neurotrophin signaling is unknown. Results: The p75NTR intracellular domain fragment, p75ICD,Expand
  • 34
  • 2
The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase*
Background: p75 neurotrophin receptor (p75NTR) signaling is modulated by dimerization and regulated intramembrane proteolysis (RIP). Results: Transmembrane sequence and TrkA but not ligands regulateExpand
  • 32
  • 2
Functional monoclonal antibodies to p75 neurotrophin receptor raised in knockout mice
In this study, p75NTREXONIII knockout mice were used as immune-naive hosts to produce functional antibodies to human p75NTR. Three monoclonal antibodies were produced and named MLR1, MLR2 and MLR3,Expand
  • 30
  • 1
G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity
Alzheimer's disease is characterized by cognitive decline, neuronal degeneration, and the accumulation of amyloid-beta (Aβ). Although, the neurotoxic Aβ peptide is widely believed to trigger neuronalExpand
  • 10
  • 1
  • PDF
Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?
The common neurotrophin receptor (p75(NTR)) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of theExpand
  • 14
  • 1