Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
- D. Matthews, J. Hosker, A. Rudenski, B. Naylor, D. Treacher, R. Turner
- Medicine, BiologyDiabetologia
- 29 June 1985
The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
In patients with type 2 diabetes the risk of diabetic complications was strongly associated with previous hyperglycaemia, with the lowest risk being in those with HbA1c values in the normal range (<6.0%).
Use and abuse of HOMA modeling.
The HOMA model has become a widely used clinical and epidemiological tool and, when used appropriately, it can yield valuable data, however, as with all models, the primary input data needs to be robust, and the data need to be interpreted carefully.
Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes…
Properties of currently available glucose-lowering agents that may guide treatment choice in individual patients with type 2 diabetes mellitus are explored.
Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of…
This briefer article should be read as an addendum to the previous full account on the management of hyperglycemia, which described the need to individualize both treatment targets and treatment strategies with an emphasis on patient-centered care and shared decision making.
10-year follow-up of intensive glucose control in type 2 diabetes.
- R. Holman, S. Paul, M. A. Bethel, D. Matthews, H. Neil
- MedicineNew England Journal of Medicine
- 9 October 2008
Despite an early loss of glycemic differences, a continued reduction in microvascular risk and emergent risk reductions for myocardial infarction and death from any cause were observed during 10 years of post-trial follow-up.
Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program
Three cases illustrate that pentoxifylline, in conjunction with intensive therapy for diabetes, may be particularly useful in reducing significant proteinuria in patients with macroalbuminuria from diabetic nephropathy.
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
Patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation, primarily at the level of the toe or metatarsal.
Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
In patients with type 2 diabetes the risk of diabetic complications was strongly associated with raised blood pressure, with the lowest risk being in those with systolic blood pressure less than 120 mm Hg.
Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of…
A briefer article on the management of hyperglycemia in patients with type 2 diabetes, with an emphasis on patientcentered care and shared decision making, is read as an addendum to the previous full account.