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The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.
The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.
Results suggest that the CORVET complex is built of subunits with distinct activities and potentially, their sequential assembly could regulate tethering and successive fusion at the late endosomes.
Gem1 and ERMES Do Not Directly Affect Phosphatidylserine Transport from ER to Mitochondria or Mitochondrial Inheritance
It is shown that ERMES and Gem1 have no direct role in the transport of phosphatidylserine from the ER to mitochondria during the synthesis ofosphatidylethanolamine (PE), as PS to PE conversion is not affected in ERmES or gem1 mutants.
An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER.
Rab cascades and tethering factors in the endomembrane system
The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8.
- H. Hou, Kanagaraj Subramanian, C. Ungermann
- BiologyProceedings of the National Academy of Sciences…
- 29 November 2005
It is found that Pfa3/Ynl326c is required for efficient localization of Vac8 to vacuoles in vivo, while Yck3 or Meh1 localization is not impaired in any of the seven DHHC deletions.
Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study.
Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial
- Yanislava Karusheva, Theresa Koessler, M. Roden
- MedicineThe American journal of clinical nutrition
- 27 August 2019
Short-term dietary reduction of BCAAs decreases postprandial insulin secretion and improves white adipose tissue metabolism and gut microbiome composition and long-term studies will be needed to evaluate the safety and metabolic efficacy in diabetes patients.
Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial
EMPA effectively reduces hepatic fat in patients with T2D with excellent glycemic control and short known disease duration, and Interestingly, EMPA also decreases circulating uric acid and raises adiponectin levels despite unchanged insulin sensitivity.
Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes
CRF is reduced in recently diagnosed type 2 diabetes but preserved in type 1 diabetes, whereas cardiac autonomic function is reducedIn both diabetes types but is strongly associated with CRF only in type1 diabetes, which supports the therapeutic concept of promoting physical fitness in the early course of diabetes.