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Hemostasis factors and aging
With advancing age, an increasing number of healthy individuals have laboratory signs of heightened coagulation enzyme activity. Such biochemical hypercoagulability might be the basis of either the… Expand
Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females
In this study we applied a new analytical strategy to investigate the relations between stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through the Infinium… Expand
Identification of a DNA methylation signature in blood cells from persons with Down Syndrome
Down Syndrome (DS) is characterized by a wide spectrum of clinical signs, which include segmental premature aging of central nervous and immune systems. Although it is well established that the… Expand
Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here… Expand
Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring
Centenarians’ offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to… Expand
Risk factors for hospital readmission of elderly patients.
BACKGROUND The aim of this study was to identify which factors were associated with a risk of hospital readmission within 3 months after discharge of a sample of elderly patients admitted to internal… Expand
Hemostasis abnormalities in patients with vascular dementia and Alzheimer's disease.
Since it has not been established to what extent abnormalities of hemostasis contribute to the occurrence and development of dementia, selected measurements of coagulation and fibrinolysis were… Expand
Von Willebrand factor in Italian centenarians.
BACKGROUND AND OBJECTIVES Subjects with blood type O have lower concentration of von Willebrand factor (VWF) than those with type A, B or AB. Since we recently observed that laboratory signs of… Expand
Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity
We developed a new statistical framework to find genetic variants associated with extreme longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large studies of age-related… Expand
Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
Objective Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests… Expand