• Publications
  • Influence
Biological monitoring of styrene exposure and possible interference of acetone co-exposure
Abstract The object of this study is the evaluation of some of the toxicokinetic effects of exposure to low concentrations of styrene, and the possible influence of simultaneous exposure to acetone.Expand
  • 29
  • 2
Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry.
OBJECTIVES To analyse the role of total 2,5-hexanedione (2,5-HD) compared with free 2,5-HD as a biological indicator of exposure to n-hexane at work. METHODS One-hundred and thirty two workers inExpand
  • 28
  • 2
Use of the CYP2E1 genotype and phenotype for the biological monitoring of occupational exposure to styrene.
The CYP2E1 has been identified as the main cytochrome P450 isoform involved in human styrene metabolism. CYP2E1 presents polymorphism in humans and the different genotypes may, at least partly, beExpand
  • 16
  • 2
Early diagnosis of n‐hexane–caused neuropathy
n‐Hexane neuropathy was studied in 20 workers exposed for prolonged periods to this solvent, and with urinary 2, 5‐hexanedione concentrations exceeding the biological exposure index recommended byExpand
  • 26
  • 1
Analysis of styrene and its metabolites in blood and urine of workers exposed to both styrene and acetone.
A purge-and-trap gas chromatographic (PT-GC) method for determining styrene concentrations in urine and blood samples has been used in the biological monitoring of workers exposed to styrene andExpand
  • 18
  • 1
Biological monitoring of occupational exposure to n-hexane by exhaled air analysis and urinalysis
SummaryTo compare two methods of biological monitoring for the evaluation of risk of occupational exposure to n-hexane, we analyzed the relationship between environmental exposure to this solvent andExpand
  • 17
  • 1
Purge-and-trap gas chromatographic determination of styrene in urine and blood. Application to exposed workers.
A simple purge-and-trap gas chromatographic method with flame ionization detection was developed for the determination of styrene in urine and blood. Styrene present in a 5 ml sample at roomExpand
  • 20
Partial conduction blocks in N‐hexane neuropathy
Nerve conduction blocks, defined by a significant reduction in amplitude or area of the compound muscle action potential at proximal compared with distal sites of stimulation, have been described inExpand
  • 26
Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane.
Although occupational exposure to n-hexane induces neurotoxic effects in the central and peripheral nervous systems, the mechanisms of its neurotoxicity remain unclear. n-Hexane is metabolized toExpand
  • 8
Adaptación transcultural y validación de la versión española del EUROQUEST
Resumen Introduccion El diagnostico especifico de la encefalopatia toxica (TE) por exposicion cronica a neurotoxicos presenta dificultades fundamentalmente por la carencia de criterios clinicos deExpand
  • 3