D. Marcellino

Publications79
h-index39
Citations4,616
Highly Influential Citations192
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Identification of Dopamine D1–D3 Receptor Heteromers
The function of dopamine D3 receptors present in the striatum has remained elusive. In the present study evidence is provided for the existence of dopamine D1–D3 receptor heteromers and for an… Expand
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Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization
There is evidence for strong functional antagonistic interactions between adenosine A2A receptors (A2ARs) and dopamine D2 receptors (D2Rs). Although a close physical interaction between both… Expand
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The discovery of central monoamine neurons gave volume transmission to the wired brain
The dawn of chemical neuroanatomy in the CNS came with the discovery and mapping of the central dopamine, noradrenaline and 5-hydroxytryptamine neurons by means of transmitter histochemistry using… Expand
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Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis
In vitro results show the ability of the CB(1) receptor agonist CP 55,940 to reduce the affinity of D(2) receptor agonist binding sites in both the dorsal and ventral striatum including the nucleus… Expand
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From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission
After Golgi-Cajal mapped neural circuits, the discovery and mapping of the central monoamine neurons opened up for a new understanding of interneuronal communication by indicating that another form… Expand
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Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis
Dopamine plays an important role in fear and anxiety modulating a cortical brake that the medial prefrontal cortex exerts on the anxiogenic output of the amygdala and have an important influence on… Expand
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Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
The results presented in this paper show that adenosine A2A receptor (A2AR) form homodimers and that homodimers but not monomers are the functional species at the cell surface. Fluorescence resonance… Expand
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Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors.
Previous results from FRET and BRET experiments and computational analysis (docking simulations) have suggested that a portion of the third intracellular loop (I3) of the human dopamine D2 receptor… Expand
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Adenosine A2A receptors, dopamine D2 receptors and their interactions in Parkinson's disease
Future therapies in Parkinson's disease may substantially build on the existence of intra‐membrane receptor–receptor interactions in DA receptor containing heteromeric receptor complexes. The A2A/D2… Expand
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Intramembrane receptor–receptor interactions: a novel principle in molecular medicine
Summary.In 1980/81 Agnati and Fuxe introduced the concept of intramembrane receptor–receptor interactions and presented the first experimental observations for their existence in crude membrane… Expand
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