• Publications
  • Influence
Selective elimination of human pluripotent stem cells by a marine natural product derivative.
The results demonstrate that selective elimination of human pluripotent stem cells can be achieved by designing cytotoxic small molecules with appropriate ABC-transporter selectivity.
Modelling the pathogenesis of X-linked distal hereditary motor neuropathy using patient-derived iPSCs
A neuronal model to investigate how mutations in the copper transporter ATP7A cause axonal degeneration in the peripheral nervous system is described.
Energy metabolism and mitochondrial defects in X-linked Charcot-Marie-Tooth (CMTX6) iPSC-derived motor neurons with the p.R158H PDK3 mutation
Induced pluripotent stem cells (iPSCs) are generated by re-programming CMTX6 fibroblasts and an isogenic control is engineered and genetic correction of the p.R158H mutation reverses the CMTx6 phenotype is demonstrated.
VMAT2 identified as a regulator of late-stage β-cell differentiation.
The present study identified reserpine and tetrabenazine (TBZ) as promoters of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (referred to henceforth as Ngn3)-positive endocrine precursors, a basis for the understanding of β-cell differentiation and its application to a cost-effective production of functional β cells for cell therapy.
A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.
The present study offers a chemical and mechanistic rationale for designing selective, safe, and simple reagents for the preparation of non-tumorigenic clinical samples.
Discovery of a Small Molecule-Dependent Photolytic Peptide.
The pair of the SQS peptide and YM-53601 discovered in the present study paves the way for designing a new small-molecule-controlled optogenetic tool.
Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library.
Chemical decontamination of iPS cell-derived neural cell mixtures.
Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.
Abnormal Platelet miRNA Profile Associated with Endometriosis
Results reveal that CCND2 may serve as a functional biomarker for the diagnosis of EM and dual pathway enrichment analysis revealed that both miRNAs may target the cyclin protein, G1/S-specific cyclin-D2 (CCND2).