• Publications
  • Influence
Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies.
Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease. Symptomatic management and prevention of these events using the fetal hemoglobin-reactivating agentExpand
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  • Open Access
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease.
Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in which neutrophil activation plays a major role. The disease is associated with chronic hemolysis withExpand
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Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea
Background Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustlyExpand
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  • Open Access
Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients
Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previousExpand
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  • Open Access
Stem cell transplant for children with sickle cell anemia: parent and patient interest.
We describe adolescents' and parents' interest in hematopoietic stem cell transplant (HSCT) as a cure for sickle cell disease (SCD) and factors associated with increased interest. We administered aExpand
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"Sustainability & Corporate Brand Equity through Corporate Social Responsibility Initiatives"
IntroductionIn modern-day society, customers are progressively more savvy (Miller, 2008) concerning the touted trustworthiness of corporate brands. Brand managers are incapable of dictating the needsExpand
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Regulatory B‐cell compartment in transfused alloimmunized and non‐alloimmunized patients with sickle cell disease
Transfusion therapy is a life‐sustaining treatment for patients with sickle cell disease (SCD), but can cause serious complications including alloimmunization. We previously reported diminishedExpand
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Humoral and cell-mediated immune responses to monovalent 2009 influenza A/H1N1 and seasonal trivalent influenza vaccines in high-risk children.
OBJECTIVE Humoral and cell-mediated immune responses to monovalent 2009 pandemic influenza A (H1N1/2009) and seasonal trivalent influenza (TIV) vaccines were evaluated in healthy children andExpand
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A child with acquired factor XIII deficiency: case report and literature review
Factor XIII (FXIII) deficiency is a rare bleeding disorder, which can result in life threatening hemorrhage. Rarer still is acquired FXIII deficiency, in which the disorder is due to autoantibodiesExpand
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Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies.
Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease. Symptomatic management and prevention of these events using the fetal hemoglobin-reactivating agentExpand
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