Share This Author
Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, 9th Edition Expert Consult Premium Edition €“ Enhanced Online Features
Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, 9th Edition Expert Consult Premium Edition €“ Enhanced Online Features - Libros de Medicina - Sistema Cardiovascular -…
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
The Seattle Heart Failure Model: Prediction of Survival in Heart Failure
The Seattle Heart Failure Model provides an accurate estimate of 1-, 2-, and 3-year survival with the use of easily obtained clinical, pharmacological, device, and laboratory characteristics.
Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF)
TNF‐α acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
The data suggest that TNF‐α acts via p38 to increase atrogin1/MAFbx gene expression in skeletal muscle, which is similar to what was found with H2O2.
Inflammatory mediators and the failing heart: past, present, and the foreseeable future.
- D. Mann
- MedicineCirculation research
- 29 November 2002
A review will summarize the tremendous growth of knowledge that has taken place in proinflammatory mediators in this field, with a focus on what the authors have learned from the negative clinical trials, as well as the potential direction of future research in this area.
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD).
Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart
- K. Lavine, S. Epelman, D. Mann
- Biology, MedicineProceedings of the National Academy of Sciences
- 27 October 2014
It is shown that distinct macrophage populations derived from embryonic and adult lineages are important determinants of tissue repair and inflammation, respectively, and suggests that therapeutics targeting distinctMacrophage lineages may serve as novel treatments for heart failure.
Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.
Among patients with HFPEF, phosphodiesterase-5 inhibition with administration of sildenafil for 24 weeks, compared with placebo, did not result in significant improvement in exercise capacity or clinical status.
Desmin mutation responsible for idiopathic dilated cardiomyopathy.
A novel missense mutation of desmin, Ile451Met, was identified as the genetic cause of idiopathic dilated cardiomyopathy, the first mutation detected in the desmin tail domain, and it suggests that the tail of Desmin plays an important functional role in cardiac tissue.