D. Mangelsdorf

Publications306
h-index127
Citations79,264
Highly Influential Citations3,636
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The nuclear receptor superfamily: The second decade
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The RXR heterodimers and orphan receptors
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
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Identification of a nuclear receptor for bile acids.
TLDR
Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor, which demonstrates a mechanism by which bile acid transcriptionally regulate their biosynthesis and enterohepatic transport.
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Role of LXRs in control of lipogenesis.
TLDR
The identification here of a synthetic, nonsteroidal LXR-selective agonist series represented by T0314407 and T0901317 revealed a novel physiological role of LXR, and suggested that the increase in plasma lipids occurs via NXR-mediated induction of the sterol regulatory element-binding protein 1 (SREBP-1) lipogenic program.
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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
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Nuclear receptors and lipid physiology: opening the X-files.
TLDR
Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.
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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
TLDR
A novel LXR target is described, the sterol regulatory element-binding protein-1c gene (SREBP-1C), which encodes a membrane-bound transcription factor of the basic helix-loop-helix-leucine zipper family and reveals a unique regulatory interplay between cholesterol and fatty acid metabolism.
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An oxysterol signalling pathway mediated by the nuclear receptor LXRα
TLDR
The results demonstrate the existence of a nuclear receptor signalling pathway for oxysterols and suggest that LXRα may be important as a sensor of cholesterol metabolites.
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