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Dopamine D1/D5 Receptors Gate the Acquisition of Novel Information through Hippocampal Long-Term Potentiation and Long-Term Depression
These findings suggest that the dopaminergic system, acting via D1/D5 receptors, gates long-term changes in synaptic strength and that these changes are a critical factor in the acquisition of novel information.
Novelty acquisition is associated with induction of hippocampal long-term depression.
Observations strongly implicate an association between novelty acquisition and LTD, and LFS given during exploration of a novel environment resulted in LTD expression in Hooded Lister, and LTD enhancement in Wistar, rats.
Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition.
Findings support a decisive role for LTD in the acquisition of object-place configuration and consolidate its candidacy as a learning mechanism.
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
The notion that both mGLUR1 and mGluR5 are critically involved in bidirectional synaptic plasticity in the CA1 region and may enable functional differences in information encoding through LTP and LTD is supported.
Pannexin1 Stabilizes Synaptic Plasticity and Is Needed for Learning
It is concluded that ATP release through Panx1 channels plays a critical role in maintaining synaptic strength and plasticity in CA1 neurons of the adult hippocampus, and provides the rationale for in-depth analysis of PanX1 function and adenosine based therapies in CNS disorders.
BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment
Data support that BDNF plays an intrinsic role in improvements of synaptic plasticity and cognition that occur in EE, which causes profound changes in neuronal and signaling levels of excitation and plasticity throughout the entire central nervous system.
A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats
The data suggest that treatment with MK801 to generate an acute psychotic episode in rats, gives rise to grave disturbances in synaptic plasticity and is associated with lasting impairments with the ability to form spatial memory.