Share This Author
Dopamine D1/D5 Receptors Gate the Acquisition of Novel Information through Hippocampal Long-Term Potentiation and Long-Term Depression
- N. Lemon, D. Manahan‐Vaughan
- Biology, PsychologyJournal of Neuroscience
- 19 July 2006
These findings suggest that the dopaminergic system, acting via D1/D5 receptors, gates long-term changes in synaptic strength and that these changes are a critical factor in the acquisition of novel information.
Novelty acquisition is associated with induction of hippocampal long-term depression.
- D. Manahan‐Vaughan, K. Braunewell
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 20 July 1999
Observations strongly implicate an association between novelty acquisition and LTD, and LFS given during exploration of a novel environment resulted in LTD expression in Hooded Lister, and LTD enhancement in Wistar, rats.
Hippocampal long-term depression: master or minion in declarative memory processes?
- A. Kemp, D. Manahan‐Vaughan
- Psychology, BiologyTrends in Neurosciences
- 1 March 2007
Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition.
- A. Kemp, D. Manahan‐Vaughan
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 25 May 2004
Findings support a decisive role for LTD in the acquisition of object-place configuration and consolidate its candidacy as a learning mechanism.
Pannexin1 Stabilizes Synaptic Plasticity and Is Needed for Learning
- N. Prochnow, A. Abdulazim, G. Zoidl
- BiologyPLoS ONE
- 20 December 2012
It is concluded that ATP release through Panx1 channels plays a critical role in maintaining synaptic strength and plasticity in CA1 neurons of the adult hippocampus, and provides the rationale for in-depth analysis of PanX1 function and adenosine based therapies in CNS disorders.
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
- S. Neyman, D. Manahan‐Vaughan
- BiologyEuropean Journal of Neuroscience
- 1 March 2008
The notion that both mGLUR1 and mGluR5 are critically involved in bidirectional synaptic plasticity in the CA1 region and may enable functional differences in information encoding through LTP and LTD is supported.
BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment
- T. Novkovic, T. Mittmann, D. Manahan‐Vaughan
- Biology, PsychologyHippocampus
- 1 January 2015
Data support that BDNF plays an intrinsic role in improvements of synaptic plasticity and cognition that occur in EE, which causes profound changes in neuronal and signaling levels of excitation and plasticity throughout the entire central nervous system.
Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning
- Sreedeep Mukherjee, D. Manahan‐Vaughan
- BiologyNeuropharmacology
- 1 March 2013
A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning.
- D. Balschun, D. Manahan‐Vaughan, T. Wagner, T. Behnisch, K. Reymann, W. Wetzel
- Biology, PsychologyLearning & memory (Cold Spring Harbor, N.Y.)
- 1 March 1999
The results indicate a specific role of group I mGluRs in certain types of synaptic plasticity and of spatial learning and the obtained retention deficit is classified as a selective impairment of memory storage.
...
...