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Comparing Deficits Following Excitotoxic and Contusion Injuries in the Thoracic and Lumbar Spinal Cord of the Adult Rat
TLDR
It is demonstrated that gray matter loss can result in significant functional deficits, including paraplegia, in the absence of a disruption of major descending pathways.
Functional Redundancy of Ventral Spinal Locomotor Pathways
TLDR
A diffuse arrangement of axons within the ventral white matter that may comprise a system of multiple descending pathways subserving spontaneous over-ground locomotion in the intact animal is supported.
Functional consequences of lumbar spinal cord contusion injuries in the adult rat.
TLDR
The data suggest that moderately-severe contusion injuries centered on the rostral segments of the lumbar enlargement induce more severe locomotor deficits than would be predicted by the histological outcome (spared white matter), suggesting that gray matter loss may play a role in functional deficits following some lUMBar contusions.
Adult rat forelimb dysfunction after dorsal cervical spinal cord injury
TLDR
The present study revealed that both anatomically and electrophysiologically complete myelotomies of the C4 spinal cord dorsal columns significantly increased the adult rat's averaged times to first attend to adhesive stickers placed on the palms of their forepaws at 1 week.
Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury
TLDR
It is demonstrated for the first time that spinal cord glial cells express PDE4 subtypes and that rolipram protects oligodendrocytes from secondary cell death following contusive SCI, and indicates that further investigations into neuroprotection and axonal regeneration with ro Lipram are warranted for treating SCI.
Both Dorsal and Ventral Spinal Cord Pathways Contribute to Overground Locomotion in the Adult Rat
TLDR
The data indicate that significant contributions to locomotion from myelinated pathways within the rat DLF can be revealed when combined with simultaneous compromise of the VLF.
Hindlimb Immobilization in a Wheelchair Alters Functional Recovery Following Contusive Spinal Cord Injury in the Adult Rat
TLDR
It is hypothesized that incompletely injured rats maximally retrain themselves while moving about in their cages over the first few weeks postinjury, and hindlimb immobilization and passive stretch may hinder or conceal the normal course of functional recovery of spinal cord injured rats.
Effects of swimming on functional recovery after incomplete spinal cord injury in rats.
TLDR
It is suggested that animals re-acquire the ability to swim only if trained and that cutaneous feedback improves the re-training process, which is the normal course of recovery of over-ground walking following moderately-severe contusion injuries at T9.
Task-specificity vs. ceiling effect: Step-training in shallow water after spinal cord injury
TLDR
The results show that training in shallowWater successfully improved stepping in shallow water, but was not able to bring about significant improvements in overground locomotion despite the fact that the shallow water provides sufficient body weight support to allow acutely injured rats to generate frequent plantar stepping.
Lasting paraplegia caused by loss of lumbar spinal cord interneurons in rats: no direct correlation with motor neuron loss.
TLDR
Interneuron loss centered on the L-2 segment induces lasting paraplegia independent of motor neuron loss and white matter damage, supporting earlier suggestions that circuitry critical to the generator of locomotor activity (the central pattern generator) resides in this area.
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