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Toward discovery science of human brain function
TLDR
We have demonstrated (i) the presence of a universal functional architecture, with remarkable stability in the functional connectome and its loci of variation across participants and centers; (ii) evidence of systematic sex differences in R-fMRI measures, as well as age-related gradients. Expand
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Age‐related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging
Diffusion tensor imaging (DTI) measures diffusion of molecular water, which can be used to calculate indices of white matter integrity. Early DTI studies of aging primarily focused on two globalExpand
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Assessing the effects of age on long white matter tracts using diffusion tensor tractography
TLDR
Aging is associated with significant white matter deterioration and this deterioration is assumed to be at least partly a consequence of myelin degeneration. Expand
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Diffusion tensor imaging of cerebral white matter integrity in cognitive aging.
In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanismsExpand
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Effects of aging on the neural correlates of successful item and source memory encoding.
To investigate the neural basis of age-related source memory (SM) deficits, young and older adults were scanned with fMRI while encoding faces, scenes, and face-scene pairs. Successful encodingExpand
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Cerebral White Matter Integrity and Cognitive Aging: Contributions from Diffusion Tensor Imaging
The integrity of cerebral white matter is critical for efficient cognitive functioning, but little is known regarding the role of white matter integrity in age-related differences in cognition.Expand
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Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study.
Event-related functional magnetic resonance imaging was used to study the effects of healthy aging on hippocampal and rhinal memory functions. Memory for past events can be based on retrievalExpand
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Disconnected aging: Cerebral white matter integrity and age-related differences in cognition
Cognition arises as a result of coordinated processing among distributed brain regions and disruptions to communication within these neural networks can result in cognitive dysfunction. CorticalExpand
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Cardiovascular and behavioral effects of aerobic exercise training in healthy older men and women.
The cardiovascular and behavioral adaptations associated with a 4-month program of aerobic exercise training were examined in 101 older men and women (mean age = 67 years). Subjects were randomlyExpand
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Age-related slowing of memory retrieval: Contributions of perceptual speed and cerebral white matter integrity
Previous research suggests that, in reaction time (RT) measures of episodic memory retrieval, the unique effects of adult age are relatively small compared to the effects aging shares with moreExpand
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