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Role of interleukin‐1β in postoperative cognitive dysfunction
Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We explored whether systemic inflammation, in response toExpand
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Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats
Background:Neuroapoptosis is induced by the administration of anesthetic agents to the young. As α2 adrenoceptor signaling plays a trophic role during development and is neuroprotective in severalExpand
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Neuroinflammation: The role and consequences
Neuroinflammation is central to the common pathology of several acute and chronic brain diseases. This review examines the consequences of excessive and prolonged neuroinflammation, particularly itsExpand
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Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
Perinatal asphyxia can result in neuronal injury with long‐term neurological and behavioral consequences. Although hypothermia may provide some modest benefit, the intervention itself can produceExpand
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The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats*
Objective:Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of the current study was to compare xenon, argon, and heliumExpand
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The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
IntroductionThe impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is aExpand
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Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain
Background:Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-methyl-d-aspartate subtype of the glutamate receptor, have been demonstrated to induce apoptoticExpand
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Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
IntroductionAcute kidney injury following surgery incurs significant mortality with no proven preventative therapy. We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) providesExpand
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Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype.
Which of the three alpha2-adrenoceptor subtypes of alpha2A, alpha2B, or alpha2C mediates the neuroprotective effect of dexmedetomidine was examined in cell culture as well as in an in vivo model ofExpand
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Thinner changes of the retinal nerve fiber layer in patients with mild cognitive impairment and Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is the most common form of dementia and patients often have visual disorders. Mild cognitive impairment (MCI) is characterized by a memory deficit when comparedExpand
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