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Role of interleukin‐1β in postoperative cognitive dysfunction
TLDR
Whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery is explored.
Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline
TLDR
Peripheral blockade of TNF-α is able to limit the release of IL-1 and prevent neuroinflammation and cognitive decline in a mouse model of surgery-induced cognitive decline, suggesting a unique therapeutic potential for preemptive treatment with anti-TNF antibody to prevent surgery- induced cognitive decline.
Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats
TLDR
In vivo dexmedetomidine dose-dependently prevented isoflurane-induced neuroapoptosis in the hippocampus, thalamus, and cortex and this neuroprotection was attenuated by treatment with atipamezole, whereas in vivo anesthetic treatment did not affect the acquisition of short-term memory, but isofLurane did induce long- term memory impairment.
Cancer recurrence after surgery: Direct and indirect effects of anesthetic agents *
TLDR
A review examines the most widely postulated mechanisms for the impact of anesthesia on neuroendocrine and immune function, and proposes that an upregulation of HIFs in tumor cells by these anesthetics may contribute to a tumor's recurrence by stimulating cytoprotective or protumorigenic behavior in residual cells.
The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats*
TLDR
These studies indicate that argon and xenon provide neuroprotection against both moderate and severe hypoxia–ischemic brain injury likely through prosurvival proteins synthesis.
The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
TLDR
Evidence that there is a temporal correlation between high-mobility group box 1 (HMGB-1), microglial activation, and cognitive dysfunction is provided, and blocking IL-1 signaling is sufficient to reduce inflammation and ameliorate the disability is suggested.
Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
TLDR
Investigation of whether xenon, an antagonist of the N‐methyl‐D‐aspartate subtype of the glutamate receptor, can enhance the neuroprotection provided by mild hypothermia suggests that low (subanesthetic) concentrations of xenon in combination with mild Hypothermia may provide a safe and effective therapy for perinatal asphyxia.
Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
TLDR
The data suggest that Dex likely activates cell survival signal pAKT via α2 adrenoceptors to reduce cell death and HMGB1 release and subsequently inhibits TLR4 signaling to provide reno-protection.
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