D. Lyden

Publications139
h-index47
Citations17,015
Highly Influential Citations589
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Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand
Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-9),… Expand
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The perivascular niche regulates breast tumor dormancy
In a significant fraction of breast cancer patients, distant metastases emerge after years or even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and what wakes them up,… Expand
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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic… Expand
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CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
Colon cancer stem cells are believed to originate from a rare population of putative CD133+ intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells expresses… Expand
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The metastatic niche: adapting the foreign soil
The 'seed and soil' hypothesis for metastasis sets forth the concept that a conducive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion… Expand
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Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
About 50% of cancer patients receive radiation therapy. Here we investigated the hypothesis that tumor response to radiation is determined not only by tumor cell phenotype but also by microvascular… Expand
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Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
During embryogenesis, endothelial cells induce organogenesis before the development of circulation. These findings suggest that endothelial cells not only form passive conduits to deliver nutrients… Expand
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Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
Emerging evidence suggests that bone marrow‐derived endothelial, hematopoietic stem and progenitor cells contribute to tissue vascularization during both embryonic and postnatal physiological… Expand
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Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
Emerging evidence suggests that bone marrow–derived endothelial, hematopoietic stem and progenitor cells contribute to tissue vascularization during both embryonic and postnatal physiological… Expand
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The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts.
Metastasis is a multistep process that requires acquisition of malignant cell phenotypes which allow tumor cells to escape from the primary tumor site. Each of the steps during metastatic progression… Expand
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