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N-Heterocyclic Carbene Catalyzed Synthesis of δ-Sultones via α,β-Unsaturated Sulfonyl Azolium Intermediates.
A limited array of reactive intermediates have enabled a wealth of discoveries in N-heterocyclic carbene organocatalysis. In this study, the viability of α,β-unsaturated sulfonyl azoliums as doubleExpand
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Whole-Cell Biotransformation of m-Ethyltoluene into 1S,6R-5-Ethyl-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylic Acid as an Approach to the C-Ring of the Binary Indole–Indoline Alkaloid Vinblastine
The title compound 3, a potential building block for the construction of analogues of the clinically important anti-cancer agent vinblastine (1), has been prepared in an efficient manner through aExpand
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Finite element modelling of strains and stresses in platinum alloy bushings for textile glass fibre production
Platinum components are now very widely used in the manufacture and processing of glass. At first sight it is, therefore, surprising that finite element modelling (FEM) is seldom used in theirExpand
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Acyl anion free N-heterocyclic carbene organocatalysis.
Reaction discovery using N-heterocyclic carbene organocatalysis has been dominated by the chemistry of acyl anion equivalents. Recent studies demonstrate that NHCs are far more diverse catalysts,Expand
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N-heterocyclic carbene-catalyzed generation of alpha,beta-unsaturated acyl imidazoliums: synthesis of dihydropyranones by their reaction with enolates.
Catalytic generation of alpha,beta-unsaturated acyl imidazolium cations and enolates has been achieved, and their involvement in a Michael addition acylation sequence exploited, to provide a range ofExpand
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N-Heterocyclic carbene-catalyzed (4+2) cycloaddition/decarboxylation of silyl dienol ethers with α,β-unsaturated acid fluorides.
Herein we report the first all-carbon N-heterocyclic carbene-catalyzed (4 + 2) cycloaddition. The reaction proceeds with α,β-unsaturated acid fluorides and silyl dienol ethers and producesExpand
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N-heterocyclic carbene-catalyzed Ireland-Coates Claisen rearrangement: synthesis of functionalized β-lactones.
The N-heterocyclic carbene (NHC)-catalyzed Claisen rearrangement of hybrid Ireland-Coates structures has been achieved, allowing the stereoselective synthesis of highly functionalized β-lactones. TheExpand
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The Discovery of Catalytic Enantioselective Polyvalent Iodine Mediated Reactions
The use of polyvalent iodine mediated reactions for the synthesis of enantiopure materials has developed into an active field of research. Recently, new chiral aryl iodides, and conditions for theirExpand
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N-Heterocyclic Carbene Catalysis via the α,β-Unsaturated Acyl Azolium
First reported less than a decade ago, the α,β-unsaturated acyl azolium has emerged as a central reactive intermediate for reaction discovery using N-heterocyclic carbene catalysis. In thisExpand
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The total synthesis of (-)-7-deoxyloganin via N-heterocyclic carbene catalyzed rearrangement of α,β-unsaturated enol esters.
The diastereoselective N-heterocyclic carbene (NHC) catalyzed rearrangement of α,β-unsaturated enol ester (S)-2b has been used to assemble dihydropyranone (S)-3b, a material embodying the bicyclicExpand
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