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CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer.
BACKGROUND & AIMS CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric… Expand
Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis.
MicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as oncogenes or tumor suppressor genes in carcinogenesis. Gastric cancer is one of the most… Expand
Increased miR‐222 in H. pylori‐associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK
Little is known about the potential role of microRNAs (miRNAs) in the carcinogenesis of gastric cancer induced by Helicobacter pylori (H. pylori). Here, we showed that microRNA‐222 (miR‐222) was… Expand
Evaluation of the Protective Immunity of a Novel Subunit Fusion Vaccine in a Murine Model of Systemic MRSA Infection
Staphylococcus aureus is a common commensal organism in humans and a major cause of bacteremia and hospital acquired infection. Because of the spread of strains resistant to antibiotics, these… Expand
Increased tumor-infiltrating CD8+Foxp3+ T lymphocytes are associated with tumor progression in human gastric cancer
- Liu-sheng Peng, Y. Zhuang, +13 authors Q. Zou
- Biology, Medicine
- Cancer Immunology, Immunotherapy
- 22 May 2012
BackgroundCD8+Foxp3+ T lymphocytes have been detected in tumors. However, the distribution, phenotypic features, and regulation of these cells in gastric cancer remain unknown.MethodsThe levels of… Expand
A dominant CD4(+) T-cell response to Helicobacter pylori reduces risk for gastric disease in humans.
BACKGROUND & AIMS Immunodominance is an important feature of antiviral, antitumor, and antibacterial cellular immune responses, but it is not well demonstrated in the immune responses against… Expand
Burkholderia pseudomallei survival in lung epithelial cells benefits from miRNA-mediated suppression of ATG10
Burkholderia pseudomallei is the causative agent of melioidosis, a disease with high mortality, which is prevalent in tropical regions of the world. A recent study shows that B. pseudomallei can… Expand
Protection against Helicobacter pylori infection by a trivalent fusion vaccine based on a fragment of urease B-UreB414
A multivalent fusion vaccine is a promising option for protection against Helicobacter pylori infection. In this study, UreB414 was identified as an antigenic fragment of urease B subunit (UreB) and… Expand
[Recombinant Helicobacter pylori urease B subunit and its biological properties].
- D. Lu, X. Mao, +6 authors P. Luo
- Biology, Medicine
- Di 1 jun yi da xue xue bao = Academic journal of…
- 1 June 2003
OBJECTIVE To perform genetic recombination of the urease B subunit (UreB) of Helicobacter pylori (Hp) and examine the biological properties of the recombinant protein. METHODS The gene fragment… Expand
Determining the immunological characteristics of a novel human monoclonal antibody developed against staphylococcal enterotoxin B
ABSTRACT Staphylococci are the main cause of nosocomial infections globally. The exotoxin staphylococcal enterotoxin B (SEB) produced by methicillin-resistant Staphylococcus aureus is a major cause… Expand