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Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells
Small interfering RNA (siRNA) and microRNA silence genes at the transcriptional, posttranscriptional, and/or translational level. Using human tissue culture cells, we show that promoter-directedExpand
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Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors
The molecular bases for species barriers to lentiviral replication are not well understood, but are of interest for explaining lentiviral pathogenesis, devising therapeutic strategies, and adaptingExpand
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Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy.
Drug susceptibility and mutations in the reverse transcriptase (RT) gene were analyzed with 167 virus isolates from 38 patients treated with nevirapine, a potent nonnucleoside inhibitor of humanExpand
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Long-term persistence of zoster vaccine efficacy.
BACKGROUND The Shingles Prevention Study (SPS) demonstrated zoster vaccine efficacy through 4 years postvaccination. A Short-Term Persistence Substudy (STPS) demonstrated persistence of vaccineExpand
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In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamicsExpand
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TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier
BackgroundHIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-levelExpand
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TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.
BACKGROUND HIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-levelExpand
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Cocaine opens the blood-brain barrier to HIV-1 invasion.
Cocaine abuse has been associated with vasculitis and stroke, and is suspected to influence the progression of AIDS dementia. Cocaine may enhance HIV-1 neuroinvasion by actions directed at theExpand
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Biologically diverse molecular variants within a single HIV-1 isolate
AIDS is a disorder characterized by a slow progressive impairment of immune function and by infection of human immunodeficiency viruses (HIV-1, HIV-2)1–4. Our knowledge of how these viruses causeExpand
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Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung.
A human immunodeficiency virus (HIV)-based vector pseudotyped with the Ebola Zaire (EboZ) viral envelope glycoprotein (GP) was recently shown to transduce murine airway epithelia cells in vivo. InExpand
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