Author pages are created from data sourced from our academic publisher partnerships and public sources.
Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells
Small interfering RNA (siRNA) and microRNA silence genes at the transcriptional, posttranscriptional, and/or translational level. Using human tissue culture cells, we show that promoter-directed… Expand
Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors
The molecular bases for species barriers to lentiviral replication are not well understood, but are of interest for explaining lentiviral pathogenesis, devising therapeutic strategies, and adapting… Expand
Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy.
Drug susceptibility and mutations in the reverse transcriptase (RT) gene were analyzed with 167 virus isolates from 38 patients treated with nevirapine, a potent nonnucleoside inhibitor of human… Expand
Long-term persistence of zoster vaccine efficacy.
- V. Morrison, G. Johnson, +21 authors M. Oxman
- Clinical infectious diseases : an official…
- 15 March 2015
BACKGROUND The Shingles Prevention Study (SPS) demonstrated zoster vaccine efficacy through 4 years postvaccination. A Short-Term Persistence Substudy (STPS) demonstrated persistence of vaccine… Expand
In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamics… Expand
TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier
BackgroundHIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-level… Expand
TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.
BACKGROUND HIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-level… Expand
Cocaine opens the blood-brain barrier to HIV-1 invasion.
Cocaine abuse has been associated with vasculitis and stroke, and is suspected to influence the progression of AIDS dementia. Cocaine may enhance HIV-1 neuroinvasion by actions directed at the… Expand
Biologically diverse molecular variants within a single HIV-1 isolate
AIDS is a disorder characterized by a slow progressive impairment of immune function and by infection of human immunodeficiency viruses (HIV-1, HIV-2)1–4. Our knowledge of how these viruses cause… Expand
Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung.
- M. Medina, G. Kobinger, +4 authors J. Wilson
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 1 November 2003
A human immunodeficiency virus (HIV)-based vector pseudotyped with the Ebola Zaire (EboZ) viral envelope glycoprotein (GP) was recently shown to transduce murine airway epithelia cells in vivo. In… Expand